Characterization of NS5A and NS5B resistance-associated substitutions from genotype 1 hepatitis C virus infected patients in a Portuguese cohort

Authors: Brandão R, Marcelino R, Gonçalves F, Diogo I, Carvalho A, Cabanas J, Costa I, Brogueira P, Ventura F, Miranda A, Mansinho K, Gomes P
Publication Year: 2018
Journal: Viruses
Link: https://www.ncbi.nlm.nih.gov/pubmed/29701642

This study is focused on the prevalent NS5 coding region resistance-associated substitutions (RASs) in DAA-naive genotype (GT)1 HCV-infected patients and their potential impact on success rates. Plasma RNA from 81 GT1 HCV-infected patients was extracted prior to an in-house nested RT-PCR of the NS5 coding region, which is followed by Sanger population sequencing. NS5A RASs were present […]
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Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals

Authors: Abecasis AB, Aerts J, Camacho RJ, Eusebio M, Gomes P, Portuguese HIVRSG, Suchard MA, Theys K, Vandamme AM, Winand R
Publication Year: 2015
Journal: AIDS
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570689/%20

Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs. This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients. The […]
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Primaquine-based ionic liquids as a novel class of antimalarial hits

Authors: D'Alessandro S, Ferraz R, Gomes A, Gomes P, Machado M, Murtinheira F, Nogueira F, Noronha J, Parapini S, Prudêncio C, Prudencio M, Teixeira C
Publication Year: 2016
Journal: RCS Advances
Link: http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C6RA10759A#!divAbstract%20

Ionic liquids derived from active pharmaceutical ingredients may open new perspectives towards low-cost rescuing of classical drugs. Thus, we have synthesized novel ionic liquids derived from the antimalarial drug primaquine, and evaluated them in vitro against three stages of malaria parasites. Results from this unprecedented approach open a new chapter in the history of antimalarial […]
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A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

Authors: Alexiev I, Balotta C, Debaisieux L, Devaux C, Fransen K, García Ribas S, Gomes P, Incardona F, Kaiser R, Lemey P, Paraschiv S, Paredes R, Peeters M, Pineda-Peña AC, Ruelle J, Sayan M, Sönnerborg A, Van den Wijngaert S, Van Laethem K, Van Ranst M, Vancutsem E, Vandamme AM, Verhofstede C, Vinken L
Publication Year: 2017
Journal: Virus Evolution
Link: https://academic.oup.com/ve/article/3/suppl_1/vew036.020/4090767%20

HIV-1 non-B subtype infections have been observed in Belgium since the 1980s. However, subtype B predominates amongst men having sex with men (MSM), whereas other subtypes are mainly associated with sub-Saharan African migrants and heterosexual risk behavior. In the last decade, subtype F1 diagnoses have increased substantially in Belgium, representing 9% of newly diagnosed and […]
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Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

Authors: Abecasis AB, Baele G, Camacho RJ, Gomes P, Pineda-Peña AC, Theys K, Van Laethem K, Vandamme AM
Publication Year: 2016
Journal: AIDS Research and Human Retroviruses
Link: https://www.liebertpub.com/doi/abs/10.1089/aid.2015.0095%20

The latest nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is indicated for human immunodeficiency virus type-1 (HIV-1) patients initiating antiretroviral treatment, but the extent of genotypic RPV resistance in treatment-naive patients outside clinical trials is poorly defined. This retrospective observational study of clinical data from Belgium and Portugal evaluates genotypic information from HIV-1 drug-naive patients […]
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Characterization of NS5A and NS5B resistance-associated substitutions from genotype 1 hepatitis C virus infected patients in a Portuguese cohort

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals

Primaquine-based ionic liquids as a novel class of antimalarial hits

A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

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