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Home / Archives for 2017

Possible Biological and Clinical Applications of Phenothiazines

  • Authors: Amaral L, Csonka Á, Molnar J, Spengler G, Varga B
  • Publication Year: 2017
  • Journal: Anticancer Research
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29061777

Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology. These compounds are able to effectively inhibit dopamine, histamine, serotonin, acetylcholine, and α-adrenergic receptors; thus, their effect and side-effect profiles are extremely diverse. Besides their antipsychotic activity, phenothiazines have a significant antimicrobial effect as well, since they can enhance the bactericidal function of macrophages and inhibit efflux pumps. They are also able to eliminate bacterial resistance plasmids and destroy bacteria by their membrane-destabilizing effect. Their antiviral, antiprotozoal, antifungal, and antiprion activities have also been described. Phenothiazines have also been proven to destroy cancer cells and sensitize them to chemotherapy. Anti-angiogenesis and anticancer stem cell activities have also been reported, and they might be applied as adjuvants in the treatment of infections and tumors in the future. Finally, phenothiazines can also be effective in the treatment of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease.
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New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria

  • Authors: Amaral L, Gajdács M, Kincses A, Spengler G
  • Publication Year: 2017
  • Journal: Molecules
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28294992

Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials. This inappropriate application and mismanagement of antibiotics have led to serious problems in the therapy of infectious diseases. Bacteria can develop resistance by various mechanisms and one of the most important factors resulting in MDR […]
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Economic Crisis and Portuguese National Health Service Physicians: Findings from a Descriptive Study of Their Perceptions and Reactions from Health Care Units in the Greater Lisbon Area

  • Authors: Gonçalves L, Perelman J, Pita Barros P, Rego I, Russo G
  • Publication Year: 2017
  • Journal: Acta Médica Portuguesa
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28555551

INTRODUCTION: In Europe, scant scientific evidence exists on the impact of economic crisis on physicians. This study aims at understanding the adjustments made by public sector physicians to the changing conditions, and their perceptions on the market for medical services in the Lisbon metropolitan area. MATERIAL AND METHODS: A random sample of 484 physicians from […]
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Canine neutrophils activate effector mechanisms in response to Leishmania infantum

  • Authors: Alexandre-Pires G, da Fonseca IP, Martins C, Passero F, Pereira M, Rocha H, Rodrigues A, Santos A, Santos M, Santos-Gomes G, Santos-Mateus D, Tomas A, Valério-Bolas A
  • Publication Year: 2017
  • Journal: Veterinary Parasitology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29173534

Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis by the phlebotomine vector. To study the interaction of dog neutrophils and L. infantum promastigotes, blood neutrophils were isolated from healthy […]
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Poor housing and stroke mortality in population over 64 years old at the parish level, in mainland Portugal

  • Authors: Cabral AJR, Cabral P, Carreira M, Fraga O Martins M, Mendes JM, Oliveira A
  • Publication Year: 2017
  • Journal: GeoJournal
  • Link: https://link.springer.com/article/10.1007/s10708-016-9712-4

Housing conditions can impact physical and mental health. In 2013, Portugal was still the fourth European Union country with the highest percentage of population without an adequately heated home in winter. Other adverse conditions are, for instance, overcrowding and living in older buildings. Some studies stress the relationship between stroke and poor living conditions in […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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