Understand the molecular epidemiology and drug-resistance mechanisms of key microbial pathogens as a foundation for improved diagnosis, treatment, and control of infectious diseases in a Global Health context, with emphasis on vulnerable populations.
2.Identify critical microbial lineages and resistance mechanisms that impact disease transmission and therapeutic outcomes;
3.Support the development of innovative antimicrobial strategies and evaluate their potential for clinical and public health use;
4.Enhance early detection and monitoring systems for infection and resistance, strengthening surveillance capacity;
5. Investigate microbial evolution and genetic adaptation to inform targeted intervention strategies;
6. Contribute to locally adapted infection control measures and capacity-building initiatives.
PRIME will introduce new research tools (especially AI-driven resistance prediction for new & repurposed drug development) and themes. Research will explore the relationship between efflux activity, virulence traits, and biofilm formation, generating novel insights into microbial pathogenesis and resistance.
The Galleria mellonella invertebrate infection model will be further developed, in combination with chemogenomic approaches, to advance microbial pathogenicity studies, drug efficacy screening, and host pathogen interaction analyses.
PRIME will expand metavirome and metagenome analyses of wastewater and cohort-related samples using whole-genome sequencing (WGS), phylogenetic and phylodynamic tools.
PRIME is a core member of international collaborative networks on AMR (eg. EUResist & EUCAST Myco), TB research (eg. ESGMYC), and genomic epidemiology of viruses (eg.ESAR), engaging with both academic consortia and public–private partnerships. These efforts aim to enhance infectious disease surveillance and pandemic preparedness, providing actionable insights into emerging microbial threats within a global health framework.
Recent Highlights
World Zoonoses Day: GHTM Highlights National One Health Research as the Week Comes to a Close
Explore GHTM’s One Health research on canine leishmaniasis and leptospirosis, advancing zoonotic disease surveillance in Portugal.
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World Zoonoses Day: GHTM research advances One Health solutions for zoonotic diseases
Explore how GHTM research is strengthening One Health through advances in leishmaniasis, leptospirosis and vector-borne diseases.
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Re.Data Launches Data Curation Week to Promote Research Data Management Resources
Discover practical resources on metadata, FAIR data, legal aspects and best practices for stronger research data management and curation.
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GHTM | IHMT NOVA strengthens its role as a scientific reference in media coverage of hantaviruses
Scientific information on hantaviruses, transmission, prevention and expert insights from GHTM | IHMT NOVA following recent media attention.
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The TEAM
