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Home / Archives for Molecules

Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

  • Authors: Oliveira JWF, Rocha HAO, de Medeiros WMTQ, Silva MS
  • Publication Year: 2019
  • Journal: Molecules
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31374887

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in […]
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New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria

  • Authors: Amaral L, Gajdács M, Kincses A, Spengler G
  • Publication Year: 2017
  • Journal: Molecules
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28294992

Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials. This inappropriate application and mismanagement of antibiotics have led to serious problems in the therapy of infectious diseases. Bacteria can develop resistance by various mechanisms and one of the most important factors resulting in MDR […]
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Chalcone derivatives: Promising starting points for drug design

  • Authors: Andrade CH, Cravo P, Gomes MN, Muratov EN, Neves BJ, Peixoto JC, Pereira M, Rosseto LP
  • Publication Year: 2017
  • Journal: Molecules
  • Link: http://www.mdpi.com/1420-3049/22/8/1210%20

Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we […]
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Targeting the mitochondrial respiratory chain of Cryptococcus through antifungal chemosensitization: A model for control of non-fermentative pathogens

  • Authors: Campbell BC, Chan KL, Faria NCG, Haff RP, Kim JH, Martins MDL
  • Journal: Molecules
  • Link: http://www.mdpi.com/1420-3049/18/8/8873

Enhanced control of species of Cryptococcus, non-fermentative yeast pathogens, was achieved by chemosensitization through co-application of certain compounds with a conventional antimicrobial drug.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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