Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

Authors: Oliveira JWF, Rocha HAO, de Medeiros WMTQ, Silva MS
Publication Year: 2019
Journal: Molecules
Link: https://www.ncbi.nlm.nih.gov/pubmed/31374887

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in […]
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New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria

Authors: Amaral L, Gajdács M, Kincses A, Spengler G
Publication Year: 2017
Journal: Molecules
Link: https://www.ncbi.nlm.nih.gov/pubmed/28294992

Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials. This inappropriate application and mismanagement of antibiotics have led to serious problems in the therapy of infectious diseases. Bacteria can develop resistance by various mechanisms and one of the most important factors resulting in MDR […]
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Chalcone derivatives: Promising starting points for drug design

Authors: Andrade CH, Cravo P, Gomes MN, Muratov EN, Neves BJ, Peixoto JC, Pereira M, Rosseto LP
Publication Year: 2017
Journal: Molecules
Link: http://www.mdpi.com/1420-3049/22/8/1210%20

Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we […]
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Targeting the mitochondrial respiratory chain of Cryptococcus through antifungal chemosensitization: A model for control of non-fermentative pathogens

Authors: Campbell BC, Chan KL, Faria NCG, Haff RP, Kim JH, Martins MDL
Journal: Molecules
Link: http://www.mdpi.com/1420-3049/18/8/8873

Enhanced control of species of Cryptococcus, non-fermentative yeast pathogens, was achieved by chemosensitization through co-application of certain compounds with a conventional antimicrobial drug.
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Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria

Chalcone derivatives: Promising starting points for drug design

Targeting the mitochondrial respiratory chain of Cryptococcus through antifungal chemosensitization: A model for control of non-fermentative pathogens

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