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Home / Archives for Neves BJ

In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases

  • Autores: Andrade CH, Neves BJ, Melo-Filho CC, Rodrigues J, Silva DC, Braga RC, Cravo P
  • Ano de Publicação: 2019
  • Journal: Current Medicinal Chemistry
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29521204

Only ~1% of all drug candidates against Neglected Tropical Diseases (NTDs) have reached clinical trials in the last decades, underscoring the need for new, safe and effective treatments. In such context, drug repositioning, which allows finding novel indications for approved drugs whose pharmacokinetic and safety profiles are already known, emerging as a promising strategy for […]
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Structural insights into a novel anticancer sulfonamide chalcone

  • Autores: Custodio JMF, Michelini LJ, De Castro MRC, Vaz WF, Neves BJ, Cravo P, Barreto FS, Filho MOM, Perez CN, Napolitano HB
  • Ano de Publicação: 2018
  • Journal: New Journal of Chemistry
  • Link: http://pubs.rsc.org/en/content/articlehtml/2018/nj/c7nj03523c

Natural products have stood out due to their wide range of biological activities. Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. Although many pharmacological activities of these classes of compounds are known, new ones have arisen lately and require detailed structural and biological analyses. Herein, we […]
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QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

  • Autores: Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo P, Muratov EN, Calit J, Bargieri DY, Costa FT, Andrade CH
  • Ano de Publicação: 2018
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845645/%20

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of […]
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Chalcone derivatives: Promising starting points for drug design

  • Autores: Andrade CH, Cravo P, Gomes MN, Muratov EN, Neves BJ, Peixoto JC, Pereira M, Rosseto LP
  • Ano de Publicação: 2017
  • Journal: Molecules
  • Link: http://www.mdpi.com/1420-3049/22/8/1210%20

Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we […]
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Modern approaches to accelerate discovery of new antischistosomal drugs

  • Autores: Andrade CH, Cravo P, Machado RB, Muratov E, Neves BJ
  • Ano de Publicação: 2016
  • Journal: Expert Opinion on Drug Discovery
  • Link: https://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1178230?journalCode=iedc20

INTRODUCTION: The almost exclusive use of only praziquantel for the treatment of schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes. Consequently, there is an urgent need for new antischistosomal drugs. The identification of leads and the generation of high quality data are crucial steps in the early stages of schistosome drug discovery […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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1349-008 Lisboa
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+351 213 652 600
+351 213 632 105

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