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Home / Archives for Cravo P

In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases

  • Authors: Andrade CH, Neves BJ, Melo-Filho CC, Rodrigues J, Silva DC, Braga RC, Cravo P
  • Publication Year: 2019
  • Journal: Current Medicinal Chemistry
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29521204

Only ~1% of all drug candidates against Neglected Tropical Diseases (NTDs) have reached clinical trials in the last decades, underscoring the need for new, safe and effective treatments. In such context, drug repositioning, which allows finding novel indications for approved drugs whose pharmacokinetic and safety profiles are already known, emerging as a promising strategy for […]
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Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene

  • Authors: Chapadense F, Machado RLD, Ventura AMRDS, Áreas A, Machado RB, Viana GR, Zalis MG, de Castro AM, Cravo P
  • Publication Year: 2019
  • Journal: Revista da Sociedade Brasileira de Medicina Tropical
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30810653

INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the […]
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Is there still room to explore cyclodextrin glycosyltransferase-producers in Brazilian biodiversity?

  • Authors: Gomes ACSM, Dos Santos SR, Ribeiro MC, Cravo P, Vieira JDG, De Souza KMC, Amaral AC
  • Publication Year: 2018
  • Journal: Anais da Academia Brasileira de Ciências
  • Link: http://www.scielo.br/scielo.php?pid=S0001-37652018000401473&script=sci_abstract&tlng=en

In the present work, different Brazilian biomes aiming to identify and select cyclodextringlycosyltransferase-producer bacteria are explored. This enzyme is responsible for converting starch to cyclodextrin, which are interesting molecules to carry other substances of economic interest applied by textile, pharmaceutical, food, and other industries. Based on the enzymatic index, 12 bacteria were selected and evaluated, […]
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Structural insights into a novel anticancer sulfonamide chalcone

  • Authors: Custodio JMF, Michelini LJ, De Castro MRC, Vaz WF, Neves BJ, Cravo P, Barreto FS, Filho MOM, Perez CN, Napolitano HB
  • Publication Year: 2018
  • Journal: New Journal of Chemistry
  • Link: http://pubs.rsc.org/en/content/articlehtml/2018/nj/c7nj03523c

Natural products have stood out due to their wide range of biological activities. Among the various naturally occurring classes, we can highlight chalcones, sulfonamides and hybrid compounds formed by both. Although many pharmacological activities of these classes of compounds are known, new ones have arisen lately and require detailed structural and biological analyses. Herein, we […]
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QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

  • Authors: Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo P, Muratov EN, Calit J, Bargieri DY, Costa FT, Andrade CH
  • Publication Year: 2018
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845645/%20

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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