In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

Authors: Cravo P, Machado RB, Leite JA, Leda T, Suwanarusk R, Bittencourt N, Albrecht L, Judice C, Lopes SCP, Lacerda MVG, Ferreira MU, Soares IS, Goh YS, Bargieri DY, Nosten F, Russell B, Rénia L, Costa FTM
Publication Year: 2018
Journal: Malaria Journal
Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2144-x%20

BACKGROUND: Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. RESULTS: Detailed epitope mapping of MAEBL […]
Read More

Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: A molecular epidemiological investigation

Authors: Abreu F, Albuquerque H, Alvarenga D, Areas AL, Brasil P, Cecilia M, Cravo P, Júnior C, Pelajo-Machado M, Peterka C, Pina-Costa A, Santelli AC, Silva S, Siqueira AM, Zalis M, Zanini G
Publication Year: 2017
Journal: The Lancet Global Health
Link: http://www.thelancet.com/journals/langlo/article/PIIS2214-109X(17)30333-9/fulltext

Background Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investigation to determine […]
Read More

Human lagochilascariasis – A rare helminthic disease

Authors: Barbosa AP, Campos DMB, Cravo P, Oliveira JAD, Ostermayer AL, Tavares GG
Publication Year: 2017
Journal: Plos Neglected Tropical Diseases
Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005510%20

Lagochilascariasis is a parasitic disease caused by a helminth of the order Ascaroidea, genus Lagochilascaris that comprises 6 species, among which only Lagochilascaris minor Leiper, 1909, is implicated in the human form of the disease. It is remarkable that the majority of cases of human lagochilascariasis in the Americas have been reported in Brazil. The […]
Read More

Chalcone derivatives: Promising starting points for drug design

Authors: Andrade CH, Cravo P, Gomes MN, Muratov EN, Neves BJ, Peixoto JC, Pereira M, Rosseto LP
Publication Year: 2017
Journal: Molecules
Link: http://www.mdpi.com/1420-3049/22/8/1210%20

Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not garnered deserved attention, especially considering their high potential as chemical sources for designing and developing new effective drugs. In this review, we […]
Read More

Modern approaches to accelerate discovery of new antischistosomal drugs

Authors: Andrade CH, Cravo P, Machado RB, Muratov E, Neves BJ
Publication Year: 2016
Journal: Expert Opinion on Drug Discovery
Link: https://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1178230?journalCode=iedc20

INTRODUCTION: The almost exclusive use of only praziquantel for the treatment of schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes. Consequently, there is an urgent need for new antischistosomal drugs. The identification of leads and the generation of high quality data are crucial steps in the early stages of schistosome drug discovery […]
Read More

In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: A molecular epidemiological investigation

Human lagochilascariasis – A rare helminthic disease

Chalcone derivatives: Promising starting points for drug design

Modern approaches to accelerate discovery of new antischistosomal drugs

About GHTM

Contacts

Funding