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Home / Archives for Malaria Journal

Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

  • Ano de Publicação: 2021
  • Journal: Malaria Journal, vol 20, art 90
  • Link: https://doi.org/10.1186/s12936-021-03620-6

ABSTRACT ‘Background:’ The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8). The CYP2C8 gene carries several polymorphisms including the more frequent minor alleles, CYP2C8*2 and CYP2C8*3. These minor alleles have been associated with decreased enzymatic activity, slowing the amodiaquine biotransformation towards DEAQ. This study […]
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Care-seeking behaviour and treatment practices for malaria in children under 5 years in Mozambique: A secondary analysis of 2011 DHS and 2015 IMASIDA datasets

  • Autores: Cassy A, Saifodine A, Candrinho B, Martins MRO, de Cunha S, Pereira FM, Samo Gudo E
  • Ano de Publicação: 2019
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30940127

BACKGROUND: In Mozambique, the prevalence of malaria in children under 5 years of age is among the highest in the world, but limited data exist on determinants of care-seeking behaviour for malaria. This study aimed at determining the trends and factors associated with care-seeking behaviour for fever among children under 5 years of age and to assess […]
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In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives

  • Autores: Albuquerque EL, da Silva Emery F, De Andrade-Neto VF, de Sena Pereira VS, Fulco UL, Katzin AM, Lobo L, Nogueira F, Oliveira JIN
  • Ano de Publicação: 2018
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30567541

BACKGROUND: Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets because the pathway is different in several steps when compared with the human host. Naphthoquinone derivatives have been described as potentially promising for the […]
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Malaria determining risk factors at the household level in two rural villages of mainland Equatorial Guinea

  • Autores: Guerra M, de Sousa B, Ndong-Mabale N, Berzosa P, Arez AP
  • Ano de Publicação: 2018
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29776367

BACKGROUND: After the introduction of an artemisinin-based combination therapy, the reduction of prevalence of malaria infections has shown a remarkable progress during the last decade. However due to the lack of a consistent malaria control programme and socioeconomic inequalities, Plasmodium infection is still one of the major cause of disease in Equatorial Guinea, namely in […]
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New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

  • Autores: Lobo L, Cabral LIL, Sena MI, Guerreiro B, Rodrigues AS, De Andrade-Neto VF, Cristiano MLS, Nogueira F
  • Ano de Publicação: 2018
  • Journal: Malaria Journal
  • Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-018-2281-x%20

Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and in vivo anti-malarial activity using, respectively, the SYBR Green I assay and […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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