Malaria determining risk factors at the household level in two rural villages of mainland Equatorial Guinea

Authors: Guerra M, de Sousa B, Ndong-Mabale N, Berzosa P, Arez AP
Publication Year: 2018
Journal: Malaria Journal
Link: https://www.ncbi.nlm.nih.gov/pubmed/29776367

BACKGROUND: After the introduction of an artemisinin-based combination therapy, the reduction of prevalence of malaria infections has shown a remarkable progress during the last decade. However due to the lack of a consistent malaria control programme and socioeconomic inequalities, Plasmodium infection is still one of the major cause of disease in Equatorial Guinea, namely in […]
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Portugal and Angola: Similarities and differences in Toxoplasma gondii seroprevalence and risk factors in pregnant women

Authors: de Sousa B, Lobo ML, Matos O, Patrocinio G, Sevivas T
Publication Year: 2017
Journal: Epidemiology & Infection
Link: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/portugal-and-angola-similarities-and-differences-in-toxoplasma-gondii-seroprevalence-and-risk-factors-in-pregnant-women/8ABAD35CD7741CC84F21302DF0BD8531

In this study we determined the presence of IgM/IgG antibodies to Toxoplasma gondii in sera of 155 and 300 pregnant women from Lisbon (Portugal) and Luanda (Angola), respectively, and evaluated the potential risk factors associated with this infection. DNA detection was performed by PCR assays targeting T. gondii regions (RE/B1). Overall, 21·9% (10·9% IgG, 10·9% […]
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Plasmodium falciparum genetic diversity in continental Equatorial Guinea before and after introduction of artemisinin based combination therapy

Authors: Arez AP, Berzosa P, de Sousa B, Guerra M, Mendes C, Ndong-Mabale N, Neres R, Salgueiro P
Publication Year: 2017
Journal: Antimicrobial Agents and Chemotherapy
Link: http://aac.asm.org/content/61/1/e02556-15.full%20

Efforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling Plasmodium falciparum malaria, and thus the study of the origin and spread of associated mutations […]
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Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia

Authors: Antunes F, Badura R, Bassat Q, Calderón EJ, de Armas Y, de Sousa B, Esteves F, Huang L, Maltez F, Matos O
Publication Year: 2016
Journal: Clinical Microbiology and Infection
Link: https://www.ncbi.nlm.nih.gov/pubmed/27021425

Pneumocystis jirovecii causes severe interstitial pneumonia (PcP) in immunosuppressed patients. This multicentre study assessed the distribution frequencies of epidemiologically relevant genetic markers of P. jirovecii in different geographic populations from Portugal, the USA, Spain, Cuba and Mozambique, and the relationship between the molecular data and the geographical and clinical information, based on a multifactorial approach. The […]
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Highly active ozonides selected against drug resistant malaria

Authors: Cabral L, Cristiano MLS, de Sousa B, Lobo L, Nogueira F
Publication Year: 2016
Journal: Memórias do Instituto Oswaldo Cruz
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957497/

Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs. Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials. We have tested three synthetic ozonides […]
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Malaria determining risk factors at the household level in two rural villages of mainland Equatorial Guinea

Portugal and Angola: Similarities and differences in Toxoplasma gondii seroprevalence and risk factors in pregnant women

Plasmodium falciparum genetic diversity in continental Equatorial Guinea before and after introduction of artemisinin based combination therapy

Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia

Highly active ozonides selected against drug resistant malaria

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