Importance of tissue sampling, laboratory methods, and patient characteristics for detection of Pneumocystis in autopsied lungs of non-immunosuppressed individuals

Authors: Bustamante R, Calderón E, de Armas Y, Gallo MJ, Matos O, Miller RF, Nevez G, Ponce C, Vargas SL
Publication Year: 2017
Journal: European Journal of Clinical Microbiology & Infectious Diseases
Link: https://link.springer.com/article/10.1007%2Fs10096-017-3006-8

To understand the epidemiological significance of Pneumocystis detection in a lung tissue sample of non-immunosuppressed individuals, we examined sampling procedures, laboratory methodology, and patient characteristics of autopsy series reported in the literature. Number of tissue specimens, DNA-extraction procedures, age and underlying diagnosis highly influence yield and are critical to understand yield differences of Pneumocystis among […]
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Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia

Authors: Antunes F, Badura R, Bassat Q, Calderón EJ, de Armas Y, de Sousa B, Esteves F, Huang L, Maltez F, Matos O
Publication Year: 2016
Journal: Clinical Microbiology and Infection
Link: https://www.ncbi.nlm.nih.gov/pubmed/27021425

Pneumocystis jirovecii causes severe interstitial pneumonia (PcP) in immunosuppressed patients. This multicentre study assessed the distribution frequencies of epidemiologically relevant genetic markers of P. jirovecii in different geographic populations from Portugal, the USA, Spain, Cuba and Mozambique, and the relationship between the molecular data and the geographical and clinical information, based on a multifactorial approach. The […]
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Pneumocystis and Pneumocystosis: first meeting of experts from Latin-American and Portuguese-speaking countries – a mini-review

Authors: Calderón EJ, de Armas Y, Esteves F, Matos O, Medrano FJ, Wissmann G
Publication Year: 2014
Journal: Expert Review of Anti-infective Therapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/24617414

The epidemiological studies presented in this meeting begin to change the misconception that since the AIDS epidemic, Pneumocystis pneumonia (PcP) has become an infrequent disease, showing that today PcP remains a major opportunistic infection in HIV-infected patients in both developed and developing countries and an emerging problem in immunocompromised patients without HIV infection worldwide.
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Importance of tissue sampling, laboratory methods, and patient characteristics for detection of Pneumocystis in autopsied lungs of non-immunosuppressed individuals

Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia

Pneumocystis and Pneumocystosis: first meeting of experts from Latin-American and Portuguese-speaking countries – a mini-review

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