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Home / Archives for 2014

Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

  • Authors: Chong AS, Cowan PJ, Crompton PD, d'Apice AJ, Doumbo OK, Gomes J, Gozzelino R, Portugal S, Ramos S, Regalado A, Silveira H, Soares MP, Tran TM, Traore B, Yilmaz B
  • Publication Year: 2014
  • Journal: Cell
  • Link: http://www.cell.com/abstract/S0092-8674(14)01425-1

Glycosylation processes are under high natural selection pressure, presumably because these can modulate resistance to infection. Here, we asked whether inactivation of the UDP-galactose:β-galactoside-α1-3-galactosyltransferase (α1,3GT) gene, which ablated the expression of the Galα1-3Galβ1-4GlcNAc-R (α-gal) glycan and allowed for the production of anti-α-gal antibodies (Abs) in humans, confers protection against Plasmodium spp. infection, the causative agent of malaria and a major driving force in human evolution.
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A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

  • Authors: Clark TG, Coll F, Glynn JR, Guerra-Assunção JA, Martin N, McNerney R, Pain A, Perdigão J, Portugal I, Viveiros M
  • Publication Year: 2014
  • Journal: Nature Communications
  • Link: http://www.nature.com/ncomms/2014/140901/ncomms5812/full/ncomms5812.html

Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an important factor in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug resistance. Several systems have been proposed to classify MTBC strains into distinct lineages and families. Here, we investigate single-nucleotide polymorphisms (SNPs) as robust (stable) markers of genetic variation for phylogenetic analysis. We identify ~92k SNP across a global collection of 1,601 genomes.
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Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

  • Authors: Alecrim MG, Brasil LW, Costa MR, Lacerda MV, Marques MM, Monteiro WM, Nascimento MT, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JL
  • Publication Year: 2014
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12

In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue.
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N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity

  • Authors: Albuquerque I, Gomes A, Gomes P, Machado M, Nogueira F, Perez B, Prudencio M, Teixeira C
  • Publication Year: 2014
  • Journal: Chemmedchem
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/24474655

Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order to restore their relevance in antimalarial chemotherapy. Following this line of thought, the design, synthesis […]
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Bis-alkylamineIndolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarialcytostatic and cytocidal activities

  • Authors: Charneira C, Figueiras M, Gut J, Lavrado J, Lopes D, Machado M, Moreira R, Nogueira F, Paulo A, Rosenthal PJ, Santos SA
  • Publication Year: 2014
  • Journal: Journal of Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24673163

To get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-alkylamine (2a-k) and N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity against chloroquine (CQ)-resistant and sensitive strains of Plasmodium falciparum.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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