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Global Health and Tropical Medicine

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Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak

Background Cape Verde is an archipelago located off the West African coast and is in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum malaria cases have been reported annually, except in 2017, when an outbreak in Praia before the rainy season led to 423 autochthonous cases. It is important to understand the […]
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Anopheles aquasalis transcriptome reveals autophagic responses to Plasmodium vivax midgut invasion

BACKGROUND: Elimination of malaria depends on mastering transmission and understanding the biological basis of Plasmodium infection in the vector. The first mosquito organ to interact with the parasite is the midgut and its transcriptomic characterization during infection can reveal effective antiplasmodial responses able to limit the survival of the parasite. The vector response to Plasmodium […]
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Anopheline antiplatelet protein from mosquito saliva regulates blood feeding behavior

The saliva of hematophagous arthropods is enriched with a complex mixture of antihemostatic molecules, the biological functions of which are largely unknown. Anopheline antiplatelet protein (AAPP) from malaria vector mosquito exhibits strong antiplatelet activity when bound directly to host collagen by its C-terminus and through its N-terminus with Ca2+-binding activity. To investigate the biological functions […]
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Making a meal of it: Mosquito spit protein controls blood feeding

A Japan-based research team led by Kanazawa University used the most up-to-date simulation techniques to determine how to make Researchers led by Kanazawa University developed a transgenic approach to inactivating the mosquito salivary protein AAPP. Transgenic mosquitos showed significantly longer probing and prediuresis times, and worse feeding success and meal sizes compared with their wild-type […]
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Oral transmission of Trypanosoma cruzi, Brazilian Amazon

In the Brazilian Amazon, the suspected source of infection in an outbreak of acute Chagas disease involving 10 patients was Euterpe oleracea (açaí berry) juice. Patient blood and juice samples contained Trypanosoma cruzi TcIV, indicating oral transmission of the Chagas disease agent. © 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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