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Home / Archives for Clark TG

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak

  • Autores: Da Veiga Leal S, Ward D, Campino S, Benavente E, Ibrahim A, Claret T, Isaías V, Monteiro D, Clark TG, Gonçalves L, Valdez T, da Luz Lima Mendonça M, Silveira H, Nogueira F
  • Ano de Publicação: 2021
  • Journal: Malaria Journal 20 172
  • Link: https://doi.org/10.1186/s12936-021-03708-z

Background Cape Verde is an archipelago located off the West African coast and is in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum malaria cases have been reported annually, except in 2017, when an outbreak in Praia before the rainy season led to 423 autochthonous cases. It is important to understand the […]
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Genome-wide analysis of Mycobacterium tuberculosis polymorphisms reveals lineage-specific associations with drug resistance

  • Autores: Oppong YEA, Phelan J, Perdigão J, Machado D, Miranda A, Portugal I, Viveiros M, Clark TG, Hibberd ML
  • Ano de Publicação: 2019
  • Journal: BMC Genomics
  • Link: https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-019-5615-3

Background Continuing evolution of the Mycobacterium tuberculosis (Mtb) complex genomes associated with resistance to anti-tuberculosis drugs is threatening tuberculosis disease control efforts. Both multi- and extensively drug resistant Mtb (MDR and XDR, respectively) are increasing in prevalence, but the full set of Mtb genes involved are not known. There is a need for increased sensitivity of genome-wide approaches in order to […]
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Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

  • Autores: Phelan JE, O’Sullivan DM, Machado D, Ramos J, Oppong YEA, Campino L, McNerney R, Hibberd ML, Viveiros M, Huggett JF, Clark TG
  • Ano de Publicação: 2019
  • Journal: Genome Medicine
  • Link: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-019-0650-x

Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely used TBProfiler webtool, which predicts resistance to 14 drugs from WGS data. However, for […]
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Genetic Diversity of norA, Coding for a Main Efflux Pump of Staphylococcus aureus

  • Autores: Costa SS, Sobkowiak B, Parreira R, Edgeworth JD, Viveiros M, Clark TG, Couto I
  • Ano de Publicação: 2019
  • Journal: Frontiers in Genetics
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30687388

NorA is the best studied efflux system of Staphylococcus aureus and therefore frequently used as a model for investigating efflux-mediated resistance in this pathogen. NorA activity is associated with resistance to fluoroquinolones, several antiseptics and disinfectants and several reports have pointed out the role of efflux systems, including NorA, as a first-line response to antimicrobials in S. aureus. […]
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Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data

  • Autores: Sobkowiak B, Glynn JR, Houben RMGJ, Mallard K, Phelan JE, Guerra-Assunção JA, Banda L, Mzembe T, Viveiros M, McNerney R, Parkhill J, Crampin AC, Clark TG
  • Ano de Publicação: 2018
  • Journal: BMC Genomics
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30107785

Mixed, polyclonal Mycobacterium tuberculosis infection occurs in natural populations. Developing an effective method for detecting such cases is important in measuring the success of treatment and reconstruction of transmission between patients. Using whole genome sequence (WGS) data, we assess two methods for detecting mixed infection: (i) a combination of the number of heterozygous sites and […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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+351 213 652 600
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