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Home / Archives for Nogueira F

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak

  • Authors: Da Veiga Leal S, Ward D, Campino S, Benavente E, Ibrahim A, Claret T, Isaías V, Monteiro D, Clark TG, Gonçalves L, Valdez T, da Luz Lima Mendonça M, Silveira H, Nogueira F
  • Publication Year: 2021
  • Journal: Malaria Journal 20 172
  • Link: https://doi.org/10.1186/s12936-021-03708-z

Background Cape Verde is an archipelago located off the West African coast and is in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum malaria cases have been reported annually, except in 2017, when an outbreak in Praia before the rainy season led to 423 autochthonous cases. It is important to understand the […]
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Structure of hierridin c, synthesis of hierridins b and c, and evidence for prevalent alkylresorcinol biosynthesis in picocyanobacteria

  • Authors: Costa M, Sampaio-Dias IE, Castelo-Branco R, Scharfenstein H, Rezende de Castro R, Silva A, Schneider MPC, Araújo MJ, Martins R, Domingues VF, Nogueira F, Camões V, Vasconcelos VM, Leão PN
  • Publication Year: 2019
  • Journal: Journal of Natural Products
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30715888

Small, single-celled planktonic cyanobacteria are ubiquitous in the world’s oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins […]
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In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives

  • Authors: Albuquerque EL, da Silva Emery F, De Andrade-Neto VF, de Sena Pereira VS, Fulco UL, Katzin AM, Lobo L, Nogueira F, Oliveira JIN
  • Publication Year: 2018
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30567541

BACKGROUND: Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets because the pathway is different in several steps when compared with the human host. Naphthoquinone derivatives have been described as potentially promising for the […]
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Clinical, laboratorial and immunological aspects of severe malaria in children from Guinea-Bissau

  • Authors: Domingos J, Casimiro A, Portugal-Calisto D, Varandas L, Nogueira F, Silva MS
  • Publication Year: 2018
  • Journal: Acta Tropica
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29684356

Malaria is a parasitic disease of which Plasmodium falciparum causes the most severe form of the disease. The immune response against Plasmodium spp. is complex and remains unclear. The present report aimed to better understand the humoral immune response in severe malaria and analyse new immunodominant antigen candidates as possible serological marker in severe malaria […]
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New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum

  • Authors: Lobo L, Cabral LIL, Sena MI, Guerreiro B, Rodrigues AS, De Andrade-Neto VF, Cristiano MLS, Nogueira F
  • Publication Year: 2018
  • Journal: Malaria Journal
  • Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-018-2281-x%20

Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and in vivo anti-malarial activity using, respectively, the SYBR Green I assay and […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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