New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum
- Authors: Lobo L, Cabral LIL, Sena MI, Guerreiro B, Rodrigues AS, De Andrade-Neto VF, Cristiano MLS, Nogueira F
- Publication Year: 2018
- Journal: Malaria Journal
- Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-018-2281-x%20
Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. Methods: A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and in vivo anti-malarial activity using, respectively, the SYBR Green I assay and […]
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