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Home / Archives for Silva MS

Variable surface glycoprotein from trypanosoma brucei undergoes cleavage by matrix metalloproteinases: An in silico approach

  • Authors: Moreno CJG, Torres T, Silva MS
  • Publication Year: 2019
  • Journal: Pathogens
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31597256

In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat. VSGs are anchored in the parasite membrane by covalent C-terminal binding to glycosylphosphatidylinositol and may be periodically removed by a phospholipase C (PLC) […]
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Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic performance in settings where Chagas disease and American cutaneous or visceral leishmaniasis are coendemic

  • Authors: Daltro RT, Leony LM, Freitas NEM, Silva ÂAO, Santos EF, Del-Rei RP, Brito MEF, Brandão-Filho SP, Gomes YM, Silva MS, Donato ST, Jeronimo SMB, Monteiro GRG, Carvalho LP, Magalhães AS, Zanchin NIT, Celedon PAF, Santos FLN
  • Publication Year: 2019
  • Journal: Journal Of Clinical Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31189586

Chimeric T. cruzi antigens have been proposed as a diagnostic tool for chronic Chagas disease (CD) in both settings where Chagas disease is endemic and those where it is not endemic. Antibody response varies in accordance to each T. cruzi strain, presenting challenges to the use of antigens lacking demonstrated cross-reactivity with Leishmania spp. Our group expressed four chimeric proteins (IBMP-8.1, […]
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Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

  • Authors: Moreno CJG, Temporão A, Torres T, Silva MS
  • Publication Year: 2019
  • Journal: International Journal of Molecular Sciences
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30934540

The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. […]
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Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

  • Authors: Oliveira JWF, Rocha HAO, de Medeiros WMTQ, Silva MS
  • Publication Year: 2019
  • Journal: Molecules
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31374887

Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in […]
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Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin

  • Authors: Amorim-Carmo B, Daniele-Silva A, Parente AMS, Oliveira JWF, Furtado AA, Carvalho E, Santos ECG, Silva MS, Silva SRB, Silva-Júnior AA, Monteiro NK, Fernandes-Pedrosa MF
  • Publication Year: 2019
  • Journal: International Journal of Molecular Sciences
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30709056

Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can be used as prototypes for the design of new drugs. The aim of this study was to characterize the structural conformation, evaluate the antimicrobial activity, and gain insight into the possible action mechanism underlying it, […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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