Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic performance in settings where Chagas disease and American cutaneous or visceral leishmaniasis are coendemic
- Autores: Daltro RT, Leony LM, Freitas NEM, Silva ÂAO, Santos EF, Del-Rei RP, Brito MEF, Brandão-Filho SP, Gomes YM, Silva MS, Donato ST, Jeronimo SMB, Monteiro GRG, Carvalho LP, Magalhães AS, Zanchin NIT, Celedon PAF, Santos FLN
- Ano de Publicação: 2019
- Journal: Journal Of Clinical Microbiology
- Link: https://www.ncbi.nlm.nih.gov/pubmed/31189586
Chimeric T. cruzi antigens have been proposed as a diagnostic tool for chronic Chagas disease (CD) in both settings where Chagas disease is endemic and those where it is not endemic. Antibody response varies in accordance to each T. cruzi strain, presenting challenges to the use of antigens lacking demonstrated cross-reactivity with Leishmania spp. Our group expressed four chimeric proteins (IBMP-8.1, […]
Ler mais