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Home / Archives for Journal Of Clinical Microbiology

Cross-Reactivity Using Chimeric Trypanosoma cruzi Antigens: Diagnostic performance in settings where Chagas disease and American cutaneous or visceral leishmaniasis are coendemic

  • Authors: Daltro RT, Leony LM, Freitas NEM, Silva ÂAO, Santos EF, Del-Rei RP, Brito MEF, Brandão-Filho SP, Gomes YM, Silva MS, Donato ST, Jeronimo SMB, Monteiro GRG, Carvalho LP, Magalhães AS, Zanchin NIT, Celedon PAF, Santos FLN
  • Publication Year: 2019
  • Journal: Journal Of Clinical Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31189586

Chimeric T. cruzi antigens have been proposed as a diagnostic tool for chronic Chagas disease (CD) in both settings where Chagas disease is endemic and those where it is not endemic. Antibody response varies in accordance to each T. cruzi strain, presenting challenges to the use of antigens lacking demonstrated cross-reactivity with Leishmania spp. Our group expressed four chimeric proteins (IBMP-8.1, […]
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Novel Single Nucleotide Polymorphism-Based Assay for Genotyping Mycobacterium avium subsp Paratuberculosis

  • Authors: Bryant J, Goldstone RJ, Inácio J, Leao C, McLuckie J, Smith DG, Stevenson K
  • Publication Year: 2016
  • Journal: Journal Of Clinical Microbiology
  • Link: http://jcm.asm.org/content/54/3/556.abstract?utm_source=TrendMDJClinMicrobiol&utm_medium=TrendMDJClinMicrobiol&utm_campaign=TrendMD_JCMCLIN_1

Typing of Mycobacterium avium subspecies paratuberculosis strains presents a challenge, since they are genetically monomorphic and traditional molecular techniques have limited discriminatory power. The recent advances and availability of whole-genome sequencing have extended possibilities for the characterization of Mycobacterium avium subspecies paratuberculosis, and whole-genome sequencing can provide a phylogenetic context to facilitate global epidemiology studies. In this study, we developed a single […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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