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Home / Archives for Leao C

Draft genome sequence of a rare pigmented mycobacterium avium subsp. paratuberculosis type C strain

  • Autores: Amaro A, Barbosa P, Botelho A, Inácio J, Leao C, Pinto C, Ramos AM, Stevenson K, Usié A
  • Ano de Publicação: 2017
  • Journal: Genome Announcements
  • Link: http://genomea.asm.org/content/5/41/e01066-17.full%20

Mycobacterium avium subsp. paratuberculosis is the causative agent of paratuberculosis. We report here the draft genome sequence of a rare pigmented M. avium subsp. paratuberculosis type C strain, comprising 58 contigs and having a genome size of 4,851,414 bp. The genome will assist in the execution of pigmentation and virulence studies on this mycobacterium.
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Novel Single Nucleotide Polymorphism-Based Assay for Genotyping Mycobacterium avium subsp Paratuberculosis

  • Autores: Bryant J, Goldstone RJ, Inácio J, Leao C, McLuckie J, Smith DG, Stevenson K
  • Ano de Publicação: 2016
  • Journal: Journal Of Clinical Microbiology
  • Link: http://jcm.asm.org/content/54/3/556.abstract?utm_source=TrendMDJClinMicrobiol&utm_medium=TrendMDJClinMicrobiol&utm_campaign=TrendMD_JCMCLIN_1

Typing of Mycobacterium avium subspecies paratuberculosis strains presents a challenge, since they are genetically monomorphic and traditional molecular techniques have limited discriminatory power. The recent advances and availability of whole-genome sequencing have extended possibilities for the characterization of Mycobacterium avium subspecies paratuberculosis, and whole-genome sequencing can provide a phylogenetic context to facilitate global epidemiology studies. In this study, we developed a single […]
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Relatedness of Mycobacterium avium subspecies hominissuis clinical isolates of human and porcine origins assessed by MLVA

  • Autores: Botelho A, Canto A, Couto I, Inácio J, Leao C, Machado D, Sanches IS, Viveiros M
  • Ano de Publicação: 2014
  • Journal: Veterinary Microbiology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25085520

In this study, the analysis of Mycobacterium avium tandem repeats (MATRs) loci was adapted to evaluate the genetic diversity of epidemiological unrelated MAH clinical strains of human (n=28) and porcine (n=69) origins, collected from diverse geographical regions across mainland Portugal. These MAH isolates were found to be genetically diverse and genotypes are randomly distributed across the country.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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