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Home / Archives for Silva MS

Trans-sialidase Protein as a Potential Serological Marker for African Trypanosomiasis

  • Authors: Teixeira AF, Pereira JG, Pestana-Ascensão S, Silva MS
  • Publication Year: 2019
  • Journal: Protein Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30604107

Trypanosoma brucei is the etiological agent of African trypanosomiasis responsible for human and animal infections. T. brucei is transmitted by infected tsetse flies. There is no vaccine for the disease and drugs available for treatment are inefficient and high toxicity. In this context, it is a priority to find antigenic targets suitable for the development […]
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Analogs of the scorpion venom peptide Stigmurin: Structural assessment, toxicity, and increased antimicrobial activity

  • Authors: Parente AMS, Daniele-Silva A, Furtado AA, Melo MA, Lacerda AF, Queiroz M, Moreno C, Santos E, Rocha HAO, Barbosa EG, Carvalho E, Silva-Júnior AA, Silva MS, Fernandes-Pedrosa MF
  • Publication Year: 2018
  • Journal: Toxins
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29670004

Scorpion venom is a rich source of biologically active components and various peptides with high-potential therapeutic use that have been characterized for their antimicrobial and antiproliferative activities. Stigmurin is a peptide identified from the Tityus stigmurus venom gland with high antibacterial and antiproliferative activities and low toxicity. Amino acid substitutions in peptides without a disulfide bridge sequence […]
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Clinical, laboratorial and immunological aspects of severe malaria in children from Guinea-Bissau

  • Authors: Domingos J, Casimiro A, Portugal-Calisto D, Varandas L, Nogueira F, Silva MS
  • Publication Year: 2018
  • Journal: Acta Tropica
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29684356

Malaria is a parasitic disease of which Plasmodium falciparum causes the most severe form of the disease. The immune response against Plasmodium spp. is complex and remains unclear. The present report aimed to better understand the humoral immune response in severe malaria and analyse new immunodominant antigen candidates as possible serological marker in severe malaria […]
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Biological and molecular characterization of trypanosoma cruzi strains from four states of Brazil

  • Authors: Ribeiro AR, Lima L, De Almeida LA, Monteiro J, Moreno CJG, Nascimento JD, De Araújo RF, Mello F, Martins LPA, Graminha MAS, Teixeira MMG, Silva MS, Steindel M, Da Rosa JA
  • Publication Year: 2018
  • Journal: American Journal of Tropical Medicine and Hygiene
  • Link: http://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0200

Chagas disease affects between six and seven million people. Its etiological agent, Trypanosoma cruzi, is classified into six discrete typing units (DTUs). The biological study of 11 T. cruzi strains presented here included four parameters: growth kinetics, parasitemia curves, rate of macrophage infection, and serology to evaluate IgM, total IgG, IgG1, IgG2a, and IgG3. Sequencing […]
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Triatoma virus structural polyprotein expression, processing and assembly into virus-like particles

  • Authors: Guérin DM, Méndez F, Querido JF, Rodríguez JF, Sánchez-Eugenia R, Silva MS
  • Publication Year: 2015
  • Journal: Journal of General Virology
  • Link: http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.071639-0#tab2%20

In contrast to the current wealth of structural information concerning dicistrovirus particle structure, very little is known about their morphogenetic pathways. Here, we describe the expression of the two ORFs encoded by the Triatoma virus (TrV) genome. TrV, a member of the Cripavirus genus of the Dicistroviridae family, infects blood-sucking insects belonging to the Triatominae […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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