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Home / Archives for American Journal of Tropical Medicine and Hygiene

Perspective Piece: Application of the relationship-based model to engagement for field trials of genetically engineered malaria vectors

  • Authors: Ana Kormos, Gregory C Lanzaro, Ethan Bier, George Dimopoulos, John M Marshall, Joao Pinto, Adionilde Aguiar dos Santos, Affane Bacar, Herodes Sousa Pontes Sacramento Rompão, Anthony A James
  • Publication Year: 2021
  • Journal: American Journal of Tropical Medicine and Hygiene, 104(3), pp 805 - 811
  • Link: https://doi.org/10.4269/ajtmh.20-0868

ABSTRACT The transition of new technologies for public health from laboratory to field is accompanied by a broadening scope of engagement challenges. Recent developments of vector control strategies involving genetically engineered mosquitoes with gene drives to assist in the eradication of malaria have drawn significant attention. Notably, questions have arisen surrounding community and regulatory engagement […]
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Biological and molecular characterization of trypanosoma cruzi strains from four states of Brazil

  • Authors: Ribeiro AR, Lima L, De Almeida LA, Monteiro J, Moreno CJG, Nascimento JD, De Araújo RF, Mello F, Martins LPA, Graminha MAS, Teixeira MMG, Silva MS, Steindel M, Da Rosa JA
  • Publication Year: 2018
  • Journal: American Journal of Tropical Medicine and Hygiene
  • Link: http://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0200

Chagas disease affects between six and seven million people. Its etiological agent, Trypanosoma cruzi, is classified into six discrete typing units (DTUs). The biological study of 11 T. cruzi strains presented here included four parameters: growth kinetics, parasitemia curves, rate of macrophage infection, and serology to evaluate IgM, total IgG, IgG1, IgG2a, and IgG3. Sequencing […]
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Case report: Yaws osteoperiostitis treated with single-dose azithromycin

  • Authors: González-Beiras C, González-Escalante Á, Ma L, McClymont K, Mitjà O, Vall-Mayans M
  • Publication Year: 2017
  • Journal: American Journal of Tropical Medicine and Hygiene
  • Link: http://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0943

The etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzathine benzylpenicillin in the […]
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Ziehl-neelsen in schistosomiasis: Much more than staining the shell and species identification

  • Authors: Belo S, Hänscheid T, Vieira S
  • Publication Year: 2016
  • Journal: American Journal of Tropical Medicine and Hygiene
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824205/

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First isolates of Leptospira spp, from rodents captured in Angola

  • Authors: Carreira T, Fortes-Gabriel E, Vieira ML
  • Publication Year: 2016
  • Journal: American Journal of Tropical Medicine and Hygiene
  • Link: http://www.ajtmh.org/content/journals/10.4269/ajtmh.15-0027

Rodents play an important role in the transmission of pathogenic Leptospira spp. However, in Angola, neither the natural reservoirs of these spirochetes nor leptospirosis diagnosis has been considered. Regarding this gap, we captured rodents in Luanda and Huambo provinces to identify circulating Leptospira spp. Rodent kidney tissue was cultured and DNA amplified and sequenced. Culture […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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