Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity

• Authors: Carrasco MP, dos Santos DJ, Gois A, Gonçalves L, Guedes RC, Gut J, Hänscheid T, Machado M, Moreira R, Newton AS, Nogueira F, Rosenthal PJ
• Publication Year: 2014
• Journal: European Journal of Medicinal Chemistry
• Link: http://www.ncbi.nlm.nih.gov/pubmed/24813880

A library comprising 44 diversely substituted aurones derivatives was synthesized by straightforward aldol condensation reactions of benzofuranones and the appropriately substituted benzaldehydes. Microwave enhanced synthesis using palladium catalyzed protocols was introduced as a powerful strategy for extending the chemical space around the aurone scaffold.
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