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Home / Archives for Carreira T

Diagnosis of Human Leptospirosis in a Clinical Setting: Real-Time PCR High Resolution Melting Analysis for Detection of Leptospira at the Onset of Disease

  • Authors: Esteves LM, Bulhões SM, Branco CC, Carreira T, Vieira ML, Gomes-Solecki M, Mota-Vieira L
  • Publication Year: 2018
  • Journal: Scientific Reports
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29907838

Currently, direct detection of Leptospira can be done in clinical laboratories by conventional and by real-time PCR (qRT-PCR). We tested a biobank of paired samples of serum and urine from the same patient (202 patients) presenting at the hospital in an area endemic for leptospirosis using qRT-PCR followed by high resolution melting (HRM) analysis. The […]
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First Detection of Borrelia burgdorferi sensu lato DNA in Serum of the Wild Boar (Sus scrofa) in Northern Portugal by Nested-PCR

  • Authors: Cabral JA, Carreira T, Coelho C, Faria AC, Nunes M, Paiva-Cardoso Md, Vale-Gonçalves HM, Veloso O, Vieira ML, Vieira-Pinto M
  • Publication Year: 2015
  • Journal: Anais do Instituto de Higiene e Medicina Tropical
  • Link: http://ihmtweb.ihmt.unl.pt/PublicacoesFB/Anais/Anais2015/index.html#31/z

Lyme borreliosis is the most common tick-borne zoonosis in the northern hemisphere. Several vertebrates are crucial in the epidemiological cycle of Borrelia burgdorferi sensu lato, but the role of wild boar as a reservoir is still unknown. Sera were collected from 90 wild boars shot in the Trás-os-Montes region, Northern Portugal (hunting season 2011/2012). In […]
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Borrelia burgdorferi sensu lato in humans in a rural area of Paraná State, Brazil

  • Authors: Carreira T, Freitas JC, Gonçalves D, Moura RA, Nunes M, Vidotto O, Vieira ML
  • Publication Year: 2015
  • Journal: Brazilian Journal of Microbiology
  • Link: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200571

This study describes the detection of Borrelia garinii and Borrelia burgdorferi sensu stricto (s.s.) in Brazilian individuals using PCR and DNA sequencing. Our results suggest that these species are emerging pathogens in this country, and additional studies are necessary to determine the epidemiological characteristics of this disease in Brazil.
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Development and evaluation of a two-step multiplex TaqMan real-time PCR assay for detection/quantification of different genospecies of Borrelia burgdorferi sensu lato

  • Authors: Nunes M, Parreira R, Carreira T, Inácio J, Vieira ML
  • Publication Year: 2017
  • Journal: Ticks and Tick-Borne Diseases
  • Link: https://www.sciencedirect.com/science/article/pii/S1877959X16302771

Nowadays, at least four clinically important B. burgdorferi sensu lato (s.l.) genospecies (B. afzelii, B. garinii, B. burgdorferi sensu stricto (s.s.) and B. lusitaniae) circulate in Portugal. Each genospecies has a different tropism that resuls in a diverse array of clinical manifestations. The standard diagnostic procedure used is normally simple, nevertheless, during the “window-period” phase, […]
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First isolates of Leptospira spp, from rodents captured in Angola

  • Authors: Carreira T, Fortes-Gabriel E, Vieira ML
  • Publication Year: 2016
  • Journal: American Journal of Tropical Medicine and Hygiene
  • Link: http://www.ajtmh.org/content/journals/10.4269/ajtmh.15-0027

Rodents play an important role in the transmission of pathogenic Leptospira spp. However, in Angola, neither the natural reservoirs of these spirochetes nor leptospirosis diagnosis has been considered. Regarding this gap, we captured rodents in Luanda and Huambo provinces to identify circulating Leptospira spp. Rodent kidney tissue was cultured and DNA amplified and sequenced. Culture […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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