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Home / Archives for Esteves LM

Diagnosis of Human Leptospirosis in a Clinical Setting: Real-Time PCR High Resolution Melting Analysis for Detection of Leptospira at the Onset of Disease

  • Autores: Esteves LM, Bulhões SM, Branco CC, Carreira T, Vieira ML, Gomes-Solecki M, Mota-Vieira L
  • Ano de Publicação: 2018
  • Journal: Scientific Reports
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29907838

Currently, direct detection of Leptospira can be done in clinical laboratories by conventional and by real-time PCR (qRT-PCR). We tested a biobank of paired samples of serum and urine from the same patient (202 patients) presenting at the hospital in an area endemic for leptospirosis using qRT-PCR followed by high resolution melting (HRM) analysis. The […]
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Human Leptospirosis: Seroreactivity and Genetic Susceptibility in the Population of Sao Miguel Island (Azores, Portugal)

  • Autores: Branco CC, Bulhões SM, Cabral R, Esteves LM, Mota FM, Mota-Vieira ML, Paiva C, Vieira ML
  • Ano de Publicação: 2014
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25255143

We conducted, in 2011, a retrospective hospital-based case-control study in the São Miguel Island population (Azores archipelago). In order to determine the seropositivity against pathogenic Leptospira after the first episode of leptospirosis, we performed a serological evaluation in 97 unrelated participants diagnosed with leptospirosis between 1992 and 2011.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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