Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

• Authors: Moreno CJG, Temporão A, Torres T, Silva MS
• Publication Year: 2019
• Journal: International Journal of Molecular Sciences
• Link: https://www.ncbi.nlm.nih.gov/pubmed/30934540

The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. […]
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