Variable surface glycoprotein from trypanosoma brucei undergoes cleavage by matrix metalloproteinases: An in silico approach

In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat. VSGs are anchored in the parasite membrane by covalent C-terminal binding to glycosylphosphatidylinositol and may be periodically removed by a phospholipase C (PLC) […]
Read More

Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

Authors: Moreno CJG, Temporão A, Torres T, Silva MS
Publication Year: 2019
Journal: International Journal of Molecular Sciences
Link: https://www.ncbi.nlm.nih.gov/pubmed/30934540

The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. […]
Read More

Variable surface glycoprotein from trypanosoma brucei undergoes cleavage by matrix metalloproteinases: An in silico approach

Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

About GHTM

Contacts

Map