GHTM

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Home / Archives for Pathogens

Impact of annual albendazole versus four-monthly test-and-treat approach of intestinal parasites on children growth — a longitudinal four-arm randomized parallel trial during two years of a community follow-up in Bengo, Angola

  • Authors: Carolina Gasparinho, Aguinaldo Kanjungo, Félix Zage, Isabel Clemente, Ana Santos-Reis, Miguel Brito, José Carlos Sousa-Figueiredo, Filomeno Fortes, Luzia Gonçalves
  • Publication Year: 2021
  • Journal: Pathogens, 10(3), art 309
  • Link: https://doi.org/10.3390/pathogens10030309

ABSTRACT Malnutrition and intestinal parasites continue to have serious impacts on growth and cognitive development of children in Angola. A longitudinal four-arm randomized parallel trial was conducted to investigate if deworming with a single annual dose of albendazole (annual-ALB) or a four-monthly test-and-treat (4TT) intestinal parasites approach at individual or household levels improve nutritional outcomes […]
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Characterization of the Rhipicephalus (Boophilus) microplus Sialotranscriptome Profile in Response to Theileria equi Infection

  • Authors: Patrícia Paulino, Gabriela Vitari, Antonio Rezende, Joana Couto, Sandra Antunes, Ana Domingos, Maristela Peckle, Carlos Massard, Flávio Araújo, Huarrisson Santos
  • Publication Year: 2021
  • Journal: Pathogens, 10(2), art 167
  • Link: https://doi.org/10.3390/pathogens10020167

ABSTRACT This study intends to characterize the sialotranscriptome profile of Rhipicephalus (Boophilus) microplus in response to Theileria equi and identify genes of interest with differential genomic expression, indicating relevant targets in the tick–protozoan interactions. The experimental design consisted of RNA sequencing from uninfected and T. equi-infected R. microplus salivary glands (SGs) to obtain transcriptomic profiles for characterization and comparison. A total of […]
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Determinants of HIV-1 Late Presentation in Patients Followed in Europe

  • Authors: Miranda MNS, Pingarilho M, Pimentel V, Martins MDRO, Vandamme A-M, Bobkova M, Böhm M, Seguin-Devaux C, Paredes R, Rubio R, Zazzi M, Incardona F, Abecasis A.
  • Publication Year: 2021
  • Journal: Pathogens, 10(7), art 835
  • Link: https://doi.org/10.3390/pathogens10070835

ABSTRACT To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to […]
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Variable surface glycoprotein from trypanosoma brucei undergoes cleavage by matrix metalloproteinases: An in silico approach

  • Authors: Moreno CJG, Torres T, Silva MS
  • Publication Year: 2019
  • Journal: Pathogens
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31597256

In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat. VSGs are anchored in the parasite membrane by covalent C-terminal binding to glycosylphosphatidylinositol and may be periodically removed by a phospholipase C (PLC) […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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