Impact of annual albendazole versus four-monthly test-and-treat approach of intestinal parasites on children growth — a longitudinal four-arm randomized parallel trial during two years of a community follow-up in Bengo, Angola

Authors: Carolina Gasparinho, Aguinaldo Kanjungo, Félix Zage, Isabel Clemente, Ana Santos-Reis, Miguel Brito, José Carlos Sousa-Figueiredo, Filomeno Fortes, Luzia Gonçalves
Publication Year: 2021
Journal: Pathogens, 10(3), art 309
Link: https://doi.org/10.3390/pathogens10030309

ABSTRACT Malnutrition and intestinal parasites continue to have serious impacts on growth and cognitive development of children in Angola. A longitudinal four-arm randomized parallel trial was conducted to investigate if deworming with a single annual dose of albendazole (annual-ALB) or a four-monthly test-and-treat (4TT) intestinal parasites approach at individual or household levels improve nutritional outcomes […]
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Characterization of the Rhipicephalus (Boophilus) microplus Sialotranscriptome Profile in Response to Theileria equi Infection

Authors: Patrícia Paulino, Gabriela Vitari, Antonio Rezende, Joana Couto, Sandra Antunes, Ana Domingos, Maristela Peckle, Carlos Massard, Flávio Araújo, Huarrisson Santos
Publication Year: 2021
Journal: Pathogens, 10(2), art 167
Link: https://doi.org/10.3390/pathogens10020167

ABSTRACT This study intends to characterize the sialotranscriptome profile of Rhipicephalus (Boophilus) microplus in response to Theileria equi and identify genes of interest with differential genomic expression, indicating relevant targets in the tick–protozoan interactions. The experimental design consisted of RNA sequencing from uninfected and T. equi-infected R. microplus salivary glands (SGs) to obtain transcriptomic profiles for characterization and comparison. A total of […]
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Determinants of HIV-1 Late Presentation in Patients Followed in Europe

Authors: Miranda MNS, Pingarilho M, Pimentel V, Martins MDRO, Vandamme A-M, Bobkova M, Böhm M, Seguin-Devaux C, Paredes R, Rubio R, Zazzi M, Incardona F, Abecasis A.
Publication Year: 2021
Journal: Pathogens, 10(7), art 835
Link: https://doi.org/10.3390/pathogens10070835

ABSTRACT To control the Human Immunodeficiency Virus (HIV) pandemic, the World Health Organization (WHO) set the 90-90-90 target to be reached by 2020. One major threat to those goals is late presentation, which is defined as an individual presenting a TCD4+ count lower than 350 cells/mm3 or an AIDS-defining event. The present study aims to […]
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Variable surface glycoprotein from trypanosoma brucei undergoes cleavage by matrix metalloproteinases: An in silico approach

Authors: Moreno CJG, Torres T, Silva MS
Publication Year: 2019
Journal: Pathogens
Link: https://www.ncbi.nlm.nih.gov/pubmed/31597256

In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat. VSGs are anchored in the parasite membrane by covalent C-terminal binding to glycosylphosphatidylinositol and may be periodically removed by a phospholipase C (PLC) […]
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Impact of annual albendazole versus four-monthly test-and-treat approach of intestinal parasites on children growth — a longitudinal four-arm randomized parallel trial during two years of a community follow-up in Bengo, Angola

Characterization of the Rhipicephalus (Boophilus) microplus Sialotranscriptome Profile in Response to Theileria equi Infection

Determinants of HIV-1 Late Presentation in Patients Followed in Europe

Variable surface glycoprotein from trypanosoma brucei undergoes cleavage by matrix metalloproteinases: An in silico approach

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