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Home / Archives for Sandra Antunes

Probing the Rhipicephalus bursa sialomes in potential anti-tick vaccine candidates: A reverse vaccinology approach

  • Autores: Joana Couto, Gonçalo Seixas, Christian Stutzer, Nicholas A Olivier, Christine Maritz-Olivier, Sandra Antunes, Ana Domingos
  • Ano de Publicação: 2021
  • Journal: Biomedicines, 9(4), art 363
  • Link: https://doi.org/10.3390/biomedicines9040363

ABSTRACT In the wake of the ‘omics’ explosion of data, reverse vaccinology approaches are being applied more readily as an alternative for the discovery of candidates for next generation diagnostics and vaccines. Promising protective antigens for the control of ticks and tick-borne diseases can be discovered by mining available omics data for immunogenic epitopes. The […]
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Comparative Proteomic Analysis of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) Tropical and Temperate Lineages: Uncovering Differences During Ehrlichia canis Infection

  • Autores: Gustavo Seron Sanches, Margarita Villar, Joana Couto, Joana Ferrolho, Isabel G Fernández de Mera, Marcos Rogério André, Darci Moraes Barros-Battesti, Rosangela Zacarias Machado, Gervásio Henrique Bechara, Lourdes Mateos-Hernández, José de la Fuente, Sandra Antunes, Ana Domingos
  • Ano de Publicação: 2021
  • Journal: Frontiers in Cellular and Infection Microbiology, 10, art 6111132
  • Link: https://doi.org/10.3389/fcimb.2020.611113

ABSTRACT The tick vector Rhipicephalus sanguineus is established as a complex of closely related species with high veterinary-medical significance, in which the presence of different genetic, morphological, and biological traits has resulted in the recognition of different lineages within taxa. One of the most striking differences in the “temperate” and “tropical” lineages of R. sanguineus (s.l.) is the vector […]
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Comparative analysis of Rhipicephalus tick salivary gland and cement elementome

  • Autores: Iván Pacheco, Eduardo Prado, Sara Artigas-Jerónimo, José Francisco Lima-Barbero, Gabriela de la Fuente, Sandra Antunes, Joana Couto, Ana Domingos, Margarita Villar, José de la Fuente
  • Ano de Publicação: 2021
  • Journal: Heliyon, 7(4), art e06721
  • Link: https://doi.org/10.1016/j.heliyon.2021.e06721

Rhipicephalus spp. (Acari: Ixodidae) ticks are obligate hematophagous arthropods, which constitute a model for the study of vector-host interactions. The chemical composition or elementome of salivary glands (SG) and cement provides information relevant for the study of protein-based complex multifunctional tissues with a key role in tick biology. In this study, we characterized the elementome of cement cones in Rhipicephalus sanguineus collected from naturally infested dogs and in SG and cement of R. bursa collected from experimentally infested rabbits at different feeding stages.
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Characterization of the Rhipicephalus (Boophilus) microplus Sialotranscriptome Profile in Response to Theileria equi Infection

  • Autores: Patrícia Paulino, Gabriela Vitari, Antonio Rezende, Joana Couto, Sandra Antunes, Ana Domingos, Maristela Peckle, Carlos Massard, Flávio Araújo, Huarrisson Santos
  • Ano de Publicação: 2021
  • Journal: Pathogens, 10(2), art 167
  • Link: https://doi.org/10.3390/pathogens10020167

ABSTRACT This study intends to characterize the sialotranscriptome profile of Rhipicephalus (Boophilus) microplus in response to Theileria equi and identify genes of interest with differential genomic expression, indicating relevant targets in the tick–protozoan interactions. The experimental design consisted of RNA sequencing from uninfected and T. equi-infected R. microplus salivary glands (SGs) to obtain transcriptomic profiles for characterization and comparison. A total of […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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