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Home / Archives for Frontiers in Cellular and Infection Microbiology

Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro

  • Autores: Inês Morais, Márcia M. Medeiros, Maria Carvalho, Judit Morello, Sara M. Teixeira, Suelma Maciel, Janice Nhantumbo, Ana Balau, Margarida T. G. Rosa, Fatima Nogueira, João Alexandre Rodrigues, Filomena A. Carvalho, Alexandra M. M. Antunes, Ana Paula Arez
  • Ano de Publicação: 2022
  • Journal: Frontiers in Cellular and Infection Microbiology, vol 12, art 840968
  • Link: https://doi.org/10.3389/fcimb.2022.840968

Mechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated with resistance to malaria in both experimental models and population studies.
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Comparative Proteomic Analysis of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) Tropical and Temperate Lineages: Uncovering Differences During Ehrlichia canis Infection

  • Autores: Gustavo Seron Sanches, Margarita Villar, Joana Couto, Joana Ferrolho, Isabel G Fernández de Mera, Marcos Rogério André, Darci Moraes Barros-Battesti, Rosangela Zacarias Machado, Gervásio Henrique Bechara, Lourdes Mateos-Hernández, José de la Fuente, Sandra Antunes, Ana Domingos
  • Ano de Publicação: 2021
  • Journal: Frontiers in Cellular and Infection Microbiology, 10, art 6111132
  • Link: https://doi.org/10.3389/fcimb.2020.611113

ABSTRACT The tick vector Rhipicephalus sanguineus is established as a complex of closely related species with high veterinary-medical significance, in which the presence of different genetic, morphological, and biological traits has resulted in the recognition of different lineages within taxa. One of the most striking differences in the “temperate” and “tropical” lineages of R. sanguineus (s.l.) is the vector […]
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Biomarkers Associated with Leishmania infantum Exposure, Infection, and Disease in Dogs

  • Autores: Campino L, Maia C
  • Ano de Publicação: 2018
  • Journal: Frontiers in Cellular and Infection Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136405/

Canine leishmaniosis (CanL) is a vector-borne disease caused by the protozoan Leishmania (Leishmania) infantum species [syn. L. (L.) infantum chagasi species in the Americas] which is transmitted by the bite of a female phlebotomine sand fly. This parasitosis is endemic and affect millions of dogs in Asia, the Americas and the Mediterranean basin. Domestic dogs are the main hosts and the main […]
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Rhipicephalus bursa sialotranscriptomic response to blood feeding and babesia ovis infection: Identification of candidate protective antigens

  • Autores: Antunes S, Couto J, Ferrolho J, Rodrigues F, Nobre J, Santos AS, Santos-Silva MM, de la Fuente J, Domingos A
  • Ano de Publicação: 2018
  • Journal: Frontiers in Cellular and Infection Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29780749

Abstract Ticks are among the most prevalent blood-feeding arthropods, and they act as vectors and reservoirs for numerous pathogens. Sialotranscriptomic characterizations of tick responses to blood feeding and pathogen infections can offer new insights into the molecular interplay occurring at the tick-host-pathogen interface. In the present study, we aimed to identify and characterize Rhipicephalus bursasalivary gland […]
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Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

  • Autores: Alberdi P, Antunes S, Ayllón N, Bonnet S, Cabezas-Cruz A, Caracappa S, de la Fuente J, Domingos AG, Estrada-Peña A, Fooks AR, Golovchenko M, Gortazar C, Grubhoffer L, Johnson N, Kocan KM, Mansfield KL, Nijhof AM, Papa A, Rego ROM, Rudenko N, Torina A, Vancova M, Villar M
  • Ano de Publicação: 2017
  • Journal: Frontiers in Cellular and Infection Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fcimb.2017.00114/full

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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