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Home / Archives for de la Fuente J

Transcriptome and Proteome Response of Rhipicephalus annulatus Tick Vector to Babesia bigemina Infection

  • Autores: Antunes S, Couto J, Ferrolho J, Sanches GS, Merino Charrez JO, De la Cruz Hernández N, Mazuz M, Villar M, Shkap V, de la Fuente J, Domingos A
  • Ano de Publicação: 2019
  • Journal: Frontiers in Physiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31001128

A system biology approach was used to gain insight into tick biology and interactions between vector and pathogen. Rhipicephalus annulatus is one of the main vectors of Babesia bigemina which has a massive impact on animal health. It is vital to obtain more information about this relationship, to better understand tick and pathogen biology, pathogen transmission dynamics, and new […]
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Functional genomics of tick vectors challenged with the cattle parasite Babesia bigemina

  • Autores: Antunes S, de la Fuente J, Domingos A, Villar M
  • Ano de Publicação: 2015
  • Journal: Methods in Molecular Biology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/25399115

Ticks are obligate hematophagous ectoparasites considered as vectors of animal diseases, having a huge economic impact in cattle industry. Babesia spp. are tick-borne pathogens that cause a disease called babesiosis in a wide range of animals and in humans. Control of tick infestations is mainly based on the use of acaricides, which have limited efficacy […]
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Rhipicephalus bursa sialotranscriptomic response to blood feeding and babesia ovis infection: Identification of candidate protective antigens

  • Autores: Antunes S, Couto J, Ferrolho J, Rodrigues F, Nobre J, Santos AS, Santos-Silva MM, de la Fuente J, Domingos A
  • Ano de Publicação: 2018
  • Journal: Frontiers in Cellular and Infection Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29780749

Abstract Ticks are among the most prevalent blood-feeding arthropods, and they act as vectors and reservoirs for numerous pathogens. Sialotranscriptomic characterizations of tick responses to blood feeding and pathogen infections can offer new insights into the molecular interplay occurring at the tick-host-pathogen interface. In the present study, we aimed to identify and characterize Rhipicephalus bursasalivary gland […]
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Antiplasmodial activity of tick defensins in a mouse model of malaria

  • Autores: Couto J, Tonk M, Ferrolho J, Antunes S, Vilcinskas A, de la Fuente J, Domingos A, Cabezas-Cruz A
  • Ano de Publicação: 2018
  • Journal: Ticks and Tick-Borne Diseases
  • Link: https://www.sciencedirect.com/science/article/pii/S1877959X17303291%20

Malaria is a mosquito-borne disease affecting millions of people mainly in Sub-Saharan Africa, Asia and some South American countries. Drug resistance to first-line antimalarial drugs (e.g. chloroquine, sulfadoxine–pyrimethamine and artemisinin) is a major constrain in malaria control. Antimicrobial peptides (AMPs) have shown promising results in controlling Plasmodium spp. parasitemia in in vitro and in vivo […]
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Artificial feeding of rhipicephalus microplus female ticks with anti calreticulin serum do not influence tick and Babesia bigemina acquisition

  • Autores: Antunes S, de la Fuente J, Domingos A, Domingues N, Lerias J, Merino O, Mosqueda J
  • Ano de Publicação: 2015
  • Journal: Ticks Tick Borne Diseases
  • Link: https://www.sciencedirect.com/science/article/pii/S1877959X14001861?via%3Dihub

Ticks are obligate haematophagous ectoparasites considered the principal vectors of disease among animals. Rhipicephalus microplus and R. annulatus ticks are the most important vectors for Babesia bigemina and B. bovis, two of the most important intraerythrocytic protozoan parasites species in cattle, responsible for babesiosis which together with anaplasmosis account for substantial economic losses in the […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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