Antiplasmodial activity of tick defensins in a mouse model of malaria

Authors: Couto J, Tonk M, Ferrolho J, Antunes S, Vilcinskas A, de la Fuente J, Domingos A, Cabezas-Cruz A
Publication Year: 2018
Journal: Ticks and Tick-Borne Diseases
Link: https://www.sciencedirect.com/science/article/pii/S1877959X17303291%20

Malaria is a mosquito-borne disease affecting millions of people mainly in Sub-Saharan Africa, Asia and some South American countries. Drug resistance to first-line antimalarial drugs (e.g. chloroquine, sulfadoxine–pyrimethamine and artemisinin) is a major constrain in malaria control. Antimicrobial peptides (AMPs) have shown promising results in controlling Plasmodium spp. parasitemia in in vitro and in vivo […]
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Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection

Authors: Borges L, Cabezas-Cruz A, Coelho LP, de la Fuente J, Do Rosário V, Domingos A, Pinheiro-Silva R, Valdés JJ
Publication Year: 2015
Journal: Parasites & Vectors
Link: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-015-1079-8%20

Malaria is a devastating infectious disease caused by Plasmodium parasites transmitted through the bites of infected Anopheles mosquitoes. Salivary glands are the only mosquito tissue invaded by Plasmodium sporozoites, being a key stage for the effective parasite transmission, making the study of Anopheles sialome highly relevant. RNA-sequencing was used to compare differential gene expression in […]
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Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

Authors: Alberdi P, Antunes S, Ayllón N, Bonnet S, Cabezas-Cruz A, Caracappa S, de la Fuente J, Domingos AG, Estrada-Peña A, Fooks AR, Golovchenko M, Gortazar C, Grubhoffer L, Johnson N, Kocan KM, Mansfield KL, Nijhof AM, Papa A, Rego ROM, Rudenko N, Torina A, Vancova M, Villar M
Publication Year: 2017
Journal: Frontiers in Cellular and Infection Microbiology
Link: https://www.frontiersin.org/articles/10.3389/fcimb.2017.00114/full

Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of […]
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Detection and phylogenetic characterization of Theileria spp. and Anaplasma marginale in Rhipicephalus bursa in Portugal

Authors: Antunes S, Cabezas-Cruz A, Domingos A, Ferrolho J, Padre L, Santos AS, Santos-Silva MM, Velez R
Publication Year: 2016
Journal: Ticks and Tick-Borne Diseases
Link: https://www.sciencedirect.com/science/article/pii/S1877959X16300048?via%3Dihub#!%20

Ticks are obligatory blood-sucking arthropod (Acari:Ixodida) ectoparasites of domestic and wild animals as well as humans. The incidence of tick-borne diseases is rising worldwide, challenging our approach toward diagnosis, treatment and control options. Rhipicephalus bursa Canestrini and Fanzago, 1877, a two-host tick widely distributed in the Palearctic Mediterranean region, is considered a multi-host tick that […]
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Antiplasmodial activity of tick defensins in a mouse model of malaria

Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection

Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases

Detection and phylogenetic characterization of Theileria spp. and Anaplasma marginale in Rhipicephalus bursa in Portugal

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