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Home / Archives for Couto J

Transcriptome and Proteome Response of Rhipicephalus annulatus Tick Vector to Babesia bigemina Infection

  • Autores: Antunes S, Couto J, Ferrolho J, Sanches GS, Merino Charrez JO, De la Cruz Hernández N, Mazuz M, Villar M, Shkap V, de la Fuente J, Domingos A
  • Ano de Publicação: 2019
  • Journal: Frontiers in Physiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31001128

A system biology approach was used to gain insight into tick biology and interactions between vector and pathogen. Rhipicephalus annulatus is one of the main vectors of Babesia bigemina which has a massive impact on animal health. It is vital to obtain more information about this relationship, to better understand tick and pathogen biology, pathogen transmission dynamics, and new […]
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Folate pathway modulation in Rhipicephalus ticks in response to infection

  • Autores: Dias F, Couto J, Ferrolho J, Seron GS, Bell-Sakyi L, Antunes S, Domingos A
  • Ano de Publicação: 2019
  • Journal: Transboundary and Emerging Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31231926

Folate pathways components were demonstrated to be present in RNA-sequencing data obtained from uninfected and pathogen-infected Rhipicephalus ticks. Here, PCR and qPCR allowed the identification of folate-related genes in Rhipicephalus spp. ticks and in the tick cell line IDE8. Genes coding for GTP cyclohydrolase I (gch-I), thymidylate synthase (ts) and 6-pyrovoyltetrahydropterin (ptps) were identified. Differential […]
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PCR detection of Ehrlichia ruminantium and Babesia bigemina in cattle from Kwara State, Nigeria: unexpected absence of infection

  • Autores: Hector E, Elelu N, Ferrolho J, Couto J, Sanches GS, Antunes S, Domingos A, Eisler MC
  • Ano de Publicação: 2019
  • Journal: Parasitology Research
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30656410

Ticks and tick-borne diseases (TBDs) continue to pose an insidious and ever-present threat to livestock and livelihoods across the globe. Two of the most significant TBDs of cattle in Africa are heartwater and babesioisis, caused by Ehrlichia ruminantium and Babesia bigemina respectively. Both pathogens are endemic in Nigeria. However, to date, little data has been […]
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Molecular heterogeneity of Rhipicephalus sanguineus sensu lato and screening for Ehrlichia canis in mainland Portugal

  • Autores: Sanches GS, Couto J, Silva-Pedrosa R, Ferrolho J, Santos AS, Santos-Silva MM, Antunes S, Domingos A
  • Ano de Publicação: 2018
  • Journal: Ticks and Tick-Borne Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29958827

The present study aimed to expand knowledge regarding the molecular characterization of R. sanguineus s.l. in Portugal and to screen for ticks naturally infected with E. canis. A total of 113 R. sanguineus s.l. were collected questing or attached to domestic and wild animals from the 18 administrative regions of mainland Portugal. All the ticks […]
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Rhipicephalus bursa sialotranscriptomic response to blood feeding and babesia ovis infection: Identification of candidate protective antigens

  • Autores: Antunes S, Couto J, Ferrolho J, Rodrigues F, Nobre J, Santos AS, Santos-Silva MM, de la Fuente J, Domingos A
  • Ano de Publicação: 2018
  • Journal: Frontiers in Cellular and Infection Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29780749

Abstract Ticks are among the most prevalent blood-feeding arthropods, and they act as vectors and reservoirs for numerous pathogens. Sialotranscriptomic characterizations of tick responses to blood feeding and pathogen infections can offer new insights into the molecular interplay occurring at the tick-host-pathogen interface. In the present study, we aimed to identify and characterize Rhipicephalus bursasalivary gland […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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