Folate pathway modulation in Rhipicephalus ticks in response to infection

Authors: Dias F, Couto J, Ferrolho J, Seron GS, Bell-Sakyi L, Antunes S, Domingos A
Publication Year: 2019
Journal: Transboundary and Emerging Diseases
Link: https://www.ncbi.nlm.nih.gov/pubmed/31231926

Folate pathways components were demonstrated to be present in RNA-sequencing data obtained from uninfected and pathogen-infected Rhipicephalus ticks. Here, PCR and qPCR allowed the identification of folate-related genes in Rhipicephalus spp. ticks and in the tick cell line IDE8. Genes coding for GTP cyclohydrolase I (gch-I), thymidylate synthase (ts) and 6-pyrovoyltetrahydropterin (ptps) were identified. Differential […]
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Duffy negative antigen is no longer a barrier to Plasmodium vivax–molecular evidences from the African West Coast (Angola and Equatorial Guinea)

Authors: Arez AP, Benito A, Berzosa P, Cano J, de Sousa B, Dias F, Do Rosário VE, Figueiredo J, Mendes C, Mora VG
Journal: Plos Neglected Tropical Diseases
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Duffy+negative+antigen+is+no+longer+a+barrier+to+Plasmodium+vivax+%E2%80%93+molecular+evidences+from+the+African+west+coast+(Angola+and+Equatorial+Guinea).

Plasmodium vivax shows a small prevalence in West and Central Africa due to the high prevalence of Duffy negative people. However, Duffy negative individuals infected with P. vivax have been reported in areas of high prevalence of Duffy positive people who may serve as supply of P. vivax strains able to invade Duffy negative erythrocytes. We investigated the presence of P. vivax in two West African countries, using blood samples and mosquitoes collected during two on-going studies.
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Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

Authors: Arez AP, Escobar C, Lobo E, Lobo L, Nogueira F, Pateira S, Teodósio R, Varandas L, Fernandes N, Dias F
Publication Year: 2015
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/25789669

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem.
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Folate pathway modulation in Rhipicephalus ticks in response to infection

Duffy negative antigen is no longer a barrier to Plasmodium vivax–molecular evidences from the African West Coast (Angola and Equatorial Guinea)

Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

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