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Home / Archives for Plos Neglected Tropical Diseases

Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host

  • Autores: David Jessula Levy, Amy Goundry, Raquel S S Laires, Tatiana F R Costa, Carlos Mendes Novo, Dennis J Grab, Jeremy C Mottram, Ana Paula C A Lima
  • Ano de Publicação: 2021
  • Journal: Plos Neglected Tropical Diseases, 15(6), art e0009526
  • Link: https://doi.org/10.1371/journal.pntd.0009526

ABSTRACT Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the central nervous system and causes severe encephalitis that is fatal if left untreated. We have previously identified ecotin-like inhibitors of serine peptidases, named ISPs, in trypanosomatid parasitic protozoa. Here, we investigated the role […]
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Microsatellite based molecular epidemiology of Leishmania infantum from re-emerging foci of visceral leishmaniasis in Armenia and pilot risk assessment by ecological niche modeling

  • Autores: Katrin Kuhls, Olga Moskalenko, Anna Sukiasyan, Dezdemonia Manukyan, Gayane Melik-Andreasyan, Liana Atshemyan, Hripsime Apresyan, Margarita Strelkova, Anja Jaeschke, Ralf Wieland, Marcus Frohme, Sofia Cortes, Ara Keshishyan
  • Ano de Publicação: 2021
  • Journal: Plos Neglected Tropical Diseases, 15(4), art e0009288
  • Link: https://doi.org/10.1371/journal.pntd.0009288

ABSTRACT ‘Background:’ Visceral leishmaniasis (VL) is re-emerging in Armenia since 1999 with 167 cases recorded until 2019. The objectives of this study were (i) to determine for the first time the genetic diversity and population structure of the causative agent of VL in Armenia; (ii) to compare these genotypes with those from most endemic regions […]
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Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis

  • Autores: Lorenzzo Lyrio Stringari, Luciana Polaco Covre, Flávia Dias Coelho da Silva, Vivian Leite de Oliveira, Maria Carolina Campana, David Jamil Hadad, Moisés Palaci, Padmini Salgame, Reynaldo Dietze, Daniel Cláudio de Oliveira Gomes, Rodrigo Ribeiro-Rodrigues
  • Ano de Publicação: 2021
  • Journal: Plos Neglected Tropical Diseases, 15(7), art e0009605
  • Link: https://doi.org/10.1371/journal.pntd.0009605

ABSTRACT ‘Background:’ Regulatory T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing excessive inflammation. However, their impact on regulating host protective immunity is not completely understood. Here, we demonstrate that Treg cells abrogate the in vitro microbicidal activity against Mtb. ‘Methods:’ We evaluated the in vitro microbicidal activity of peripheral blood mononuclear […]
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Efficient transplacental IgG transfer in women infected with Zika virus during pregnancy

  • Autores: Singh T, Lopez CA, Giuberti C, Dennis ML, Itell HL, Heimsath HJ, Webster HS, Roark HK, Merçon de Vargas PR, Hall A, Corey RG, Swamy GK, Dietze R, Lazear HM, Permar SR
  • Ano de Publicação: 2019
  • Journal: Plos Neglected Tropical Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31449521

Zika virus (ZIKV) is a newly-identified infectious cause of congenital disease. Transplacental transfer of maternal IgG to the fetus plays an important role in preventing many neonatal infections. However, antibody transfer may also have negative consequences, such as mediating enhancement of flavivirus infections in early life, or trafficking of virus immune complexes to the fetal […]
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A computational method for the identification of dengue, zika and chikungunya virus species and genotypes

  • Autores: Fonseca V, Libin PJK, Theys K, Faria NR, Nunes MRT, Restovic MI, Freire M, Giovanetti M, Cuypers L, Nowé A, Abecasis A, Deforche K, Santiago GA, Siqueira IC, San EJ, Machado KCB, Azevedo V, Filippis AMB, Cunha RVD, Pybus OG, Vandamme AM, Alcantara LCJ, De Oliveira T
  • Ano de Publicação: 2019
  • Journal: Plos Neglected Tropical Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31067235

In recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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