Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host
- Autores: David Jessula Levy, Amy Goundry, Raquel S S Laires, Tatiana F R Costa, Carlos Mendes Novo, Dennis J Grab, Jeremy C Mottram, Ana Paula C A Lima
- Ano de Publicação: 2021
- Journal: Plos Neglected Tropical Diseases, 15(6), art e0009526
- Link: https://doi.org/10.1371/journal.pntd.0009526
ABSTRACT Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the central nervous system and causes severe encephalitis that is fatal if left untreated. We have previously identified ecotin-like inhibitors of serine peptidases, named ISPs, in trypanosomatid parasitic protozoa. Here, we investigated the role […]
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