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Home / Archives for Theys K

Drivers of HIV-1 transmission: The Portuguese case

  • Autores: Pineda-Peña AC, Pingarilho M, Li G, Vrancken B, Libin P, Gomes P, Camacho RJ, Theys K, Abecasis AB, Portuguese Hiv-1 Resistance Study Group
  • Ano de Publicação: 2019
  • Journal: PLoS One
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31568476

BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were […]
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A computational method for the identification of dengue, zika and chikungunya virus species and genotypes

  • Autores: Fonseca V, Libin PJK, Theys K, Faria NR, Nunes MRT, Restovic MI, Freire M, Giovanetti M, Cuypers L, Nowé A, Abecasis A, Deforche K, Santiago GA, Siqueira IC, San EJ, Machado KCB, Azevedo V, Filippis AMB, Cunha RVD, Pybus OG, Vandamme AM, Alcantara LCJ, De Oliveira T
  • Ano de Publicação: 2019
  • Journal: Plos Neglected Tropical Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31067235

In recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to […]
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An Evolutionary Model-Based Approach To Quantify the Genetic Barrier to Drug Resistance in Fast-Evolving Viruses and Its Application to HIV-1 Subtypes and Integrase Inhibitors

  • Autores: Theys K, Libin PJK, Van Laethem K, Abecasis AB
  • Ano de Publicação: 2019
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31109980

Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resistance can be difficult to capture, particularly for agents […]
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Time to harmonize dengue nomenclature and classification

  • Autores: Alcantara LCJ, Cuypers L, Libin PJK, Muñoz-Jordán J, Nowé A, Santiago GA, Simmonds P, Theys K, Vandamme AM
  • Ano de Publicação: 2018
  • Journal: Viruses
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213058/

Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus’s ongoing global spread. Persistent […]
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The impact of HIV-1 within-host evolution on transmission dynamics

  • Autores: Theys K, Libin P, Pieneda-Peña AC, Nowé A, Vandamme AM, Abecasis AB
  • Ano de Publicação: 2018
  • Journal: Current Opinion in Virology
  • Link: https://www.sciencedirect.com/science/article/pii/S1879625717301372?via%3Dihub%20

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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