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Home / Archives for Libin P

Drivers of HIV-1 transmission: The Portuguese case

  • Authors: Pineda-Peña AC, Pingarilho M, Li G, Vrancken B, Libin P, Gomes P, Camacho RJ, Theys K, Abecasis AB, Portuguese Hiv-1 Resistance Study Group
  • Publication Year: 2019
  • Journal: PLoS One
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31568476

BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were […]
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The impact of HIV-1 within-host evolution on transmission dynamics

  • Authors: Theys K, Libin P, Pieneda-Peña AC, Nowé A, Vandamme AM, Abecasis AB
  • Publication Year: 2018
  • Journal: Current Opinion in Virology
  • Link: https://www.sciencedirect.com/science/article/pii/S1879625717301372?via%3Dihub%20

The adaptive potential of HIV-1 is a vital mechanism to evade host immune responses and antiviral treatment. However, high evolutionary rates during persistent infection can impair transmission efficiency and alter disease progression in the new host, resulting in a delicate trade-off between within-host virulence and between-host infectiousness. This trade-off is visible in the disparity in […]
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PhyloGeoTool: interactively exploring large phylogenies in an epidemiological context

  • Authors: Baele G, Bezenchek A, EucoHIV Study Group, Incardona F, Libin P, Nowé A, Sönnerborg A, Theys K, Vandamme AM, Vanden Eynden E
  • Publication Year: 2017
  • Journal: Bioinformatics
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28961923

MOTIVATION: Clinicians, health officials and researchers are interested in the epidemic spread of pathogens in both space and time to support the optimization of intervention measures and public health policies. Large sequence databases of virus sequences provide an interesting opportunity to study this spread through phylogenetic analysis. To infer knowledge from large phylogenetic trees, potentially […]
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Zika genomics urgently need standardized and curated reference sequences

  • Authors: Abecasis AB, Cuypers L, Dallmeier K, Libin P, Pineda-Peña AC, Theys K, Vandamme AM
  • Publication Year: 2017
  • Journal: PLoS Pathogens
  • Link: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006528

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Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning

  • Authors: Ceccherini-Silberstein F, Cento V, Cuypers L, Di Maio VC, Libin P, Lunar MM, Nevens F, Nowé A, Poljak M, Schrooten Y, Theys K, Van Laethem K, Vandamme AM
  • Publication Year: 2017
  • Journal: Infection Genetics and Evolution
  • Link: https://www.sciencedirect.com/science/article/pii/S1567134817301582?via%3Dihub

Resistance-associated variants (RAVs) have been shown to influence treatment response to direct-acting antivirals (DAAs) and first generation NS3/4A protease inhibitors (PIs) in particular. Interpretation of hepatitis C virus (HCV) genotypic drug resistance remains a challenge, especially in patients who previously failed DAA therapy and need to be retreated with a second DAA based regimen. Bayesian […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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