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Home / Archives for Camacho RJ

Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology

  • Authors: Vasylyeva TI, du Plessis L, Pineda-Peña AC, Kühnert D, Lemey P, Vandamme AM, Gomes P, Camacho RJ, Pybus OG, Abecasis AB, Faria NR
  • Publication Year: 2019
  • Journal: Journal of Infectious Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30805610

BACKGROUND: Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies. METHODS: Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific […]
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Drivers of HIV-1 transmission: The Portuguese case

  • Authors: Pineda-Peña AC, Pingarilho M, Li G, Vrancken B, Libin P, Gomes P, Camacho RJ, Theys K, Abecasis AB, Portuguese Hiv-1 Resistance Study Group
  • Publication Year: 2019
  • Journal: PLoS One
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31568476

BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were […]
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Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals

  • Authors: Abecasis AB, Aerts J, Camacho RJ, Eusebio M, Gomes P, Portuguese HIVRSG, Suchard MA, Theys K, Vandamme AM, Winand R
  • Publication Year: 2015
  • Journal: AIDS
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570689/%20

Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs. This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients. The […]
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Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

  • Authors: Abecasis AB, Baele G, Camacho RJ, Gomes P, Pineda-Peña AC, Theys K, Van Laethem K, Vandamme AM
  • Publication Year: 2016
  • Journal: AIDS Research and Human Retroviruses
  • Link: https://www.liebertpub.com/doi/abs/10.1089/aid.2015.0095%20

The latest nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is indicated for human immunodeficiency virus type-1 (HIV-1) patients initiating antiretroviral treatment, but the extent of genotypic RPV resistance in treatment-naive patients outside clinical trials is poorly defined. This retrospective observational study of clinical data from Belgium and Portugal evaluates genotypic information from HIV-1 drug-naive patients […]
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Limited cross-border infections in patients newly diagnosed with HIV in Europe

  • Authors: Abecasis AB, Albert J, Åsjö B, Balotta C, Beshkov D, Camacho RJ, Clotet B, Coughlan S, De Wit S, Frentz D, Griskevicius A, Grossman Z, Hamouda O, Horban A, Jørgensen LB, Kolupajeva T, Korn K, Kostrikis LG, Kücherer C, Liitsola K, Linka M, Nielsen C, Otelea D, Paraskevis D, Paredes R, Poljak M, Schmit JC, Sönnerborg A, Staneková D, Stanojevic M, Struck D, Vandamme AM, Wensing AMJ
  • Publication Year: 2013
  • Journal: Retrovirology
  • Link: http://www.retrovirology.com/content/10/1/36

International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections within single countries. In this study, phylogenetic associations among HIV of newly diagnosed patients were determined across Europe.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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