GHTM

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Home / Archives for Portuguese HIVRSG

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals

  • Authors: Abecasis AB, Aerts J, Camacho RJ, Eusebio M, Gomes P, Portuguese HIVRSG, Suchard MA, Theys K, Vandamme AM, Winand R
  • Publication Year: 2015
  • Journal: AIDS
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570689/%20

Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs. This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients. The […]
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Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine

  • Authors: Camacho RJ, Gomes P, Portuguese HIVRSG, Rhee SY, Theys K, Vandamme AM
  • Publication Year: 2015
  • Journal: Clinical Microbiology and Infection
  • Link: http://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(15)00299-2/fulltext%20

Rilpivirine is a second-generation nonnucleoside reverse-transcriptase inhibitor (NNRTI) currently indicated for first-line therapy, but its clinical benefit for HIV-1 infected patients failing first-generation NNRTIs is largely undefined. This study quantified the extent of genotypic rilpivirine resistance in viral isolates from 1212 patients upon failure of efavirenz- or nevirapine-containing antiretroviral treatment, of whom more than respectively […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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