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Home / Archives for Abecasis AB

Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology

  • Authors: Vasylyeva TI, du Plessis L, Pineda-Peña AC, Kühnert D, Lemey P, Vandamme AM, Gomes P, Camacho RJ, Pybus OG, Abecasis AB, Faria NR
  • Publication Year: 2019
  • Journal: Journal of Infectious Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30805610

BACKGROUND: Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies. METHODS: Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific […]
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Drivers of HIV-1 transmission: The Portuguese case

  • Authors: Pineda-Peña AC, Pingarilho M, Li G, Vrancken B, Libin P, Gomes P, Camacho RJ, Theys K, Abecasis AB, Portuguese Hiv-1 Resistance Study Group
  • Publication Year: 2019
  • Journal: PLoS One
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31568476

BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were […]
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Geographic dispersal and genetic diversity of tick-borne phleboviruses (Phenuiviridae, Phlebovirus) as revealed by the analysis of L segment sequences

  • Authors: Pimentel V, Afonso R, Nunes M, Vieira ML, Bravo-Barriga D, Frontera E, Martinez M, Pereira A, Maia C, Paiva-Cardoso MDN, Freitas FB, Abecasis AB, Parreira R
  • Publication Year: 2019
  • Journal: Ticks and Tick-Borne Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31078467

The large diversity of new tick-borne phleboviruses, and the negative impacts of the virulent viruses on human/animal health have led to a growing interest in their analysis. In this report, new insights are brought out into the diversity of putative phleboviruses circulating in Portugal (both the continental territory and the islands of São Miguel, in […]
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An Evolutionary Model-Based Approach To Quantify the Genetic Barrier to Drug Resistance in Fast-Evolving Viruses and Its Application to HIV-1 Subtypes and Integrase Inhibitors

  • Authors: Theys K, Libin PJK, Van Laethem K, Abecasis AB
  • Publication Year: 2019
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31109980

Viral pathogens causing global disease burdens are often characterized by high rates of evolutionary changes. The extensive viral diversity at baseline can shorten the time to escape from therapeutic or immune selective pressure and alter mutational pathways. The impact of genotypic background on the barrier to resistance can be difficult to capture, particularly for agents […]
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Molecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineages

  • Authors: Correia V, Abecasis AB, Rebelo-de-Andrade H
  • Publication Year: 2018
  • Journal: Virology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30029011

Influenza neuraminidase (NA) is under selective pressure (SP) of both host immune system and drug use. Here, we assembled large datasets of NA sequences of worldwide circulating viruses to estimate the global and site-specific SP acting on all current subtypes/lineages of human influenza NA. An overall negative SP of similar magnitude and a prevalence of […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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