Molecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineages

• Autores: Correia V, Abecasis AB, Rebelo-de-Andrade H
• Ano de Publicação: 2018
• Journal: Virology
• Link: https://www.ncbi.nlm.nih.gov/pubmed/30029011

Influenza neuraminidase (NA) is under selective pressure (SP) of both host immune system and drug use. Here, we assembled large datasets of NA sequences of worldwide circulating viruses to estimate the global and site-specific SP acting on all current subtypes/lineages of human influenza NA. An overall negative SP of similar magnitude and a prevalence of […]
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