Molecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineages

Authors: Correia V, Abecasis AB, Rebelo-de-Andrade H
Publication Year: 2018
Journal: Virology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30029011

Influenza neuraminidase (NA) is under selective pressure (SP) of both host immune system and drug use. Here, we assembled large datasets of NA sequences of worldwide circulating viruses to estimate the global and site-specific SP acting on all current subtypes/lineages of human influenza NA. An overall negative SP of similar magnitude and a prevalence of […]
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Negeviruses found in multiple species of mosquitoes from southern Portugal: Isolation, genetic diversity, and replication in insect cell culture

Authors: Abecasis A, Carapeta S, de Almeida AP, de Matos AP, do Bem B, Esteves A, Lopes A, McGuinness J, Parreira R, Piedade J
Publication Year: 2015
Journal: Virology
Link: https://www.sciencedirect.com/science/article/pii/S0042682215002329%20

In this report, an RT-PCR approach based on the use of degenerate primers allowed the identification of negeviruses in four different species of mosquitoes (Ochlerotatus caspius, Culex pipiens, Cx. theileri and Cx. univittatus) collected in southern Portugal. The genomes of two of these viruses, sequenced to full completion, were shown to encode all the proteins […]
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Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits

Authors: De Baets G, Dekeersmaeker N, Li G, Megens S, Moutschen M, Rousseau F, Schrooten Y, Schymkowitz J, Vaira D, Van Laethem K, Vandamme AM
Publication Year: 2014
Journal: Virology
Link: http://www.ncbi.nlm.nih.gov/pubmed/24889250

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I).
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Molecular footprints of selective pressure in the neuraminidase gene of currently circulating human influenza subtypes and lineages

Negeviruses found in multiple species of mosquitoes from southern Portugal: Isolation, genetic diversity, and replication in insect cell culture

Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits

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