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Home / Archives for Cuypers L

Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium

  • Autores: Vinken L, Fransen K, Cuypers L, Alexiev I, Balotta C, Debaisieux L, Seguin-Devaux C, García Ribas S, Gomes P, Incardona F, Kaiser R, Ruelle J, Sayan M, Paraschiv S, Paredes R, Peeters M, Sönnerborg A, Vancutsem E, Vandamme AM, Van den Wijngaert S, Van Ranst M, Verhofstede C, Stadler T, Lemey P, Van Laethem K
  • Ano de Publicação: 2019
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30972053

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this […]
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A computational method for the identification of dengue, zika and chikungunya virus species and genotypes

  • Autores: Fonseca V, Libin PJK, Theys K, Faria NR, Nunes MRT, Restovic MI, Freire M, Giovanetti M, Cuypers L, Nowé A, Abecasis A, Deforche K, Santiago GA, Siqueira IC, San EJ, Machado KCB, Azevedo V, Filippis AMB, Cunha RVD, Pybus OG, Vandamme AM, Alcantara LCJ, De Oliveira T
  • Ano de Publicação: 2019
  • Journal: Plos Neglected Tropical Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31067235

In recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to […]
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Time to harmonize dengue nomenclature and classification

  • Autores: Alcantara LCJ, Cuypers L, Libin PJK, Muñoz-Jordán J, Nowé A, Santiago GA, Simmonds P, Theys K, Vandamme AM
  • Ano de Publicação: 2018
  • Journal: Viruses
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213058/

Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus’s ongoing global spread. Persistent […]
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Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

  • Autores: Aragri M, Balog D, Ceccherini-Silberstein F, Cento V, Cuypers L, Di Maio VC, Fabeni L, Focà A, Marascio N, Nevens F, Perno CF, Pineda-Peña AC, Schrooten Y, Torti C, Van Laethem K, Vandamme AM, Vrancken B
  • Ano de Publicação: 2017
  • Journal: BMC Evolutionary Biology
  • Link: https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-017-0913-3

In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic […]
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Zika genomics urgently need standardized and curated reference sequences

  • Autores: Abecasis AB, Cuypers L, Dallmeier K, Libin P, Pineda-Peña AC, Theys K, Vandamme AM
  • Ano de Publicação: 2017
  • Journal: PLoS Pathogens
  • Link: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006528

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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