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Home / Archives for Frontiers in Microbiology

Experimental Evidence for Limited in vivo Virulence of Mycobacterium africanum

  • Autores: Cá B, Fonseca KL, Sousa J, Maceiras AR, Machado D, Sanca L, Rabna P, Rodrigues PNS, Viveiros M, Saraiva M
  • Ano de Publicação: 2019
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31552007

Tuberculosis remains a public health problem and a main cause of death to humans. Both Mycobacterium tuberculosis and Mycobacterium africanum cause tuberculosis. In contrast to M. tuberculosis, which is geographically spread, M. africanum is restricted to West Africa. Differences have also been found in the growth rate and type of disease caused by M. africanum, globally suggesting an attenuation of this bacteria. In […]
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Mycobacterial aminoglycoside acetyltransferases: A little of drug resistance, and a lot of other roles

  • Autores: Sanz-García F, Anoz-Carbonell E, Pérez-Herrán E, Martin C, Lucía A, Rodrigues L, Ainsa JA
  • Ano de Publicação: 2019
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30761098

Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility since they are related with low level resistance to these antibiotics (while high level aminoglycoside resistance is due to mutations in the ribosome). Instead, aminoglycoside acetyltransferases contribute to other bacterial […]
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Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium

  • Autores: Vinken L, Fransen K, Cuypers L, Alexiev I, Balotta C, Debaisieux L, Seguin-Devaux C, García Ribas S, Gomes P, Incardona F, Kaiser R, Ruelle J, Sayan M, Paraschiv S, Paredes R, Peeters M, Sönnerborg A, Vancutsem E, Vandamme AM, Van den Wijngaert S, Van Ranst M, Verhofstede C, Stadler T, Lemey P, Van Laethem K
  • Ano de Publicação: 2019
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30972053

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this […]
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Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence

  • Autores: Cambau E, lecorche E, Machado D, Mougari F, Viveiros M
  • Ano de Publicação: 2018
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2018.03072/full

Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of efflux systems, which is mostly unexplored. In this perspective, we discuss known efflux pumps involved in M. tuberculosis drug resistance and virulence and […]
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Morphological characteristics of Schistosoma mansoni PZQ-resistant and -susceptible strains are different in presence of Praziquantel

  • Autores: Afonso A, Allegretti SM, Anibal FF, Belo S, Carrilho E, Corrêa SAP, de Oliveira RN, Mendes T, Pinto-Almeida A, Tomas A
  • Ano de Publicação: 2016
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2016.00594/full

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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