Mycobacterial aminoglycoside acetyltransferases: A little of drug resistance, and a lot of other roles

Autores: Sanz-García F, Anoz-Carbonell E, Pérez-Herrán E, Martin C, Lucía A, Rodrigues L, Ainsa JA
Ano de Publicação: 2019
Journal: Frontiers in Microbiology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30761098

Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility since they are related with low level resistance to these antibiotics (while high level aminoglycoside resistance is due to mutations in the ribosome). Instead, aminoglycoside acetyltransferases contribute to other bacterial […]
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A real-time PCR tool for the surveillance of zoonotic Onchocerca lupi in dogs, cats and potential vectors

Autores: Latrofa MS, Annoscia G, Colella V, Cavalera MA, Maia C, Martin C, Šlapeta J, Otranto D
Ano de Publicação: 2018
Journal: Plos Neglected Tropical Diseases
Link: https://www.ncbi.nlm.nih.gov/pubmed/29617361

The ocular onchocercosis is caused by the zoonotic parasite Onchocerca lupi (Spirurida: Onchocercidae). A major hindrance to scientific progress is the absence of a reliable diagnostic test in affected individuals. Microscopic examination of skin snip sediments and the identification of adults embedded in ocular nodules are seldom performed and labour-intensive. A quantitative real-time PCR (qPCR) […]
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Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs

Autores: Colella V, Maia C, Pereira A, Gonçalves N, Caruso M, Martin C, Cardoso L, Campino L, Scandale I, Otranto D
Ano de Publicação: 2018
Journal: Plos Neglected Tropical Diseases
Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006218

The genus Onchocerca encompasses parasitic nematodes including Onchocerca volvulus, causative agent of river blindness in humans, and the zoonotic Onchocerca lupi infecting dogs and cats. In dogs, O. lupi adult worms cause ocular lesions of various degrees while humans may bear the brunt of zoonotic onchocercosis with patients requiring neurosurgical intervention because of central nervous system localization of nematodes. Though the zoonotic potential […]
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Mycobacterial aminoglycoside acetyltransferases: A little of drug resistance, and a lot of other roles

A real-time PCR tool for the surveillance of zoonotic Onchocerca lupi in dogs, cats and potential vectors

Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs

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