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Home / Archives for Martin C

Mycobacterial aminoglycoside acetyltransferases: A little of drug resistance, and a lot of other roles

  • Autores: Sanz-García F, Anoz-Carbonell E, Pérez-Herrán E, Martin C, Lucía A, Rodrigues L, Ainsa JA
  • Ano de Publicação: 2019
  • Journal: Frontiers in Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30761098

Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility since they are related with low level resistance to these antibiotics (while high level aminoglycoside resistance is due to mutations in the ribosome). Instead, aminoglycoside acetyltransferases contribute to other bacterial […]
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A real-time PCR tool for the surveillance of zoonotic Onchocerca lupi in dogs, cats and potential vectors

  • Autores: Latrofa MS, Annoscia G, Colella V, Cavalera MA, Maia C, Martin C, Šlapeta J, Otranto D
  • Ano de Publicação: 2018
  • Journal: Plos Neglected Tropical Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29617361

The ocular onchocercosis is caused by the zoonotic parasite Onchocerca lupi (Spirurida: Onchocercidae). A major hindrance to scientific progress is the absence of a reliable diagnostic test in affected individuals. Microscopic examination of skin snip sediments and the identification of adults embedded in ocular nodules are seldom performed and labour-intensive. A quantitative real-time PCR (qPCR) […]
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Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs

  • Autores: Colella V, Maia C, Pereira A, Gonçalves N, Caruso M, Martin C, Cardoso L, Campino L, Scandale I, Otranto D
  • Ano de Publicação: 2018
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006218

The genus Onchocerca encompasses parasitic nematodes including Onchocerca volvulus, causative agent of river blindness in humans, and the zoonotic Onchocerca lupi infecting dogs and cats. In dogs, O. lupi adult worms cause ocular lesions of various degrees while humans may bear the brunt of zoonotic onchocercosis with patients requiring neurosurgical intervention because of central nervous system localization of nematodes. Though the zoonotic potential […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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