Mycobacterial aminoglycoside acetyltransferases: A little of drug resistance, and a lot of other roles

• Authors: Sanz-García F, Anoz-Carbonell E, Pérez-Herrán E, Martin C, Lucía A, Rodrigues L, Ainsa JA
• Publication Year: 2019
• Journal: Frontiers in Microbiology
• Link: https://www.ncbi.nlm.nih.gov/pubmed/30761098

Aminoglycoside acetyltransferases are important determinants of resistance to aminoglycoside antibiotics in most bacterial genera. In mycobacteria, however, aminoglycoside acetyltransferases contribute only partially to aminoglycoside susceptibility since they are related with low level resistance to these antibiotics (while high level aminoglycoside resistance is due to mutations in the ribosome). Instead, aminoglycoside acetyltransferases contribute to other bacterial […]
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