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Home / Archives for Afonso A

Morphological characteristics of Schistosoma mansoni PZQ-resistant and -susceptible strains are different in presence of Praziquantel

  • Autores: Afonso A, Allegretti SM, Anibal FF, Belo S, Carrilho E, Corrêa SAP, de Oliveira RN, Mendes T, Pinto-Almeida A, Tomas A
  • Ano de Publicação: 2016
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2016.00594/full

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Sesquiterpenes effects on DNA of Schistosoma mansoni after in vivo treatment

  • Autores: de Oliveira RN, Ferreira PM, Calado M, Belo S, Afonso A, Garcia VL, Oliveira ASS, de Lurdes Sierpe Jeraldo V, dos Santos KR, Allegretti SM
  • Ano de Publicação: 2018
  • Journal: Gene Reports
  • Link: https://www.sciencedirect.com/science/article/pii/S2452014418300372?via%3Dihub

Schistosomiasis is a chronic Neglected Tropical Disease that can be debilitating, particularly children, of tropical and subtropical regions presenting an enormous global health and economic burden. Notoriously for over 30 years, the praziquantel (PZQ) is the only drug used for treatment of disease. For this reason, the search for new schistosomicidal drugs is a priority. […]
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Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice

  • Autores: Feitosa KA, Zaia MG, Rodrigues V, Castro CA, Correia RO, Pinto FG, Rossi KNZP, Avó LRS, Afonso A, Anibal FF
  • Ano de Publicação: 2018
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778335/

Schistosomiasis is an important parasitic disease caused by Schistosoma mansoni, an intravascular trematode. Schistosomiasis treatment is limited to just one drug, Praziquantel (PZQ). Thus, studies on new antischistosomal compounds are of fundamental importance to disease control. Here we report on the effects of Mentha piperita L. compounds – menthol and menthone – in association with acetylsalicylic acid (ASA) […]
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The role of efflux pumps in Schistosoma mansoni Praziquantel resistant phenotype

  • Autores: Afonso A, Armada A, Belo S, Carrilho E, Mendes T, Pinto-Almeida A, Viveiros M
  • Ano de Publicação: 2015
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140147%20

Schistosomiasis is a neglected disease caused by a trematode of the genus Schistosoma that is second only to malaria in public health significance in Africa, South America, and Asia. Praziquantel (PZQ) is the drug of choice to treat this disease due to its high cure rates and no significant side effects. However, in the last […]
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Participation of leukotrienes in the immune modulation of oral tolerance

  • Autores: Afonso A, Carrilho E, de Freitas Anibal F, de Matos AP, de Oliveira SR, Faccioli LH, Frantz FG, Nomizo A
  • Ano de Publicação: 2017
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2017.00242/full

Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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