Sesquiterpenes effects on DNA of Schistosoma mansoni after in vivo treatment

Autores: de Oliveira RN, Ferreira PM, Calado M, Belo S, Afonso A, Garcia VL, Oliveira ASS, de Lurdes Sierpe Jeraldo V, dos Santos KR, Allegretti SM
Ano de Publicação: 2018
Journal: Gene Reports
Link: https://www.sciencedirect.com/science/article/pii/S2452014418300372?via%3Dihub

Schistosomiasis is a chronic Neglected Tropical Disease that can be debilitating, particularly children, of tropical and subtropical regions presenting an enormous global health and economic burden. Notoriously for over 30 years, the praziquantel (PZQ) is the only drug used for treatment of disease. For this reason, the search for new schistosomicidal drugs is a priority. […]
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Human gastric hyperinfection by Anisakis simplex: A severe and unusual presentation and a brief review

Autores: Baptista-Fernandes T, Belo S, Castro I, Ferreira PM, Mansinho K, Paixao P, Pinto-Marques P, Rodrigues M, Roque L, Toscano C
Ano de Publicação: 2017
Journal: International Journal of Infectious Diseases
Link: https://www.ncbi.nlm.nih.gov/pubmed/28882665

Anisakiasis is an emerging marine food-borne zoonosis resulting from the accidental ingestion of Anisakis larvae, through the consumption of raw or undercooked infected seafood products. The first case of human gastric hyperinfection by Anisakis simplex with an unusual and severe presentation, occurring in a Portuguese woman, is described in this article. Over 140 anisakid larvae […]
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Curcumin generates oxidative stress and induces apoptosis in adult schistosoma mansoni worms

Autores: Afonso A, Belo S, Cunha WR, Curti C, De Aguiar DP, De Paula RG, Ferreira PM, Magalhães LG, Morais ER, Moscardini MBM, Ouchida AT, Rodrigues V
Ano de Publicação: 2016
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167135

Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates how CUR influences the induction of apoptosis and oxidative stress in couples of […]
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