Phylogenetic Studies

Authors: Kuhls K, Maurício I
Publication Year: 2019
Journal: Methods in Molecular Biology
Link: https://europepmc.org/abstract/med/30980297

Phylogenetics is an important component of the systems biology approach. Knowledge about evolution of the genus Leishmania is essential to understand various aspects of basic biology of these parasites, such as parasite-host or parasite-vector relationships, biogeography, or epidemiology. Here, we present a comprehensive guideline for performing phylogenetic studies based on DNA sequence data, but with […]
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Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome®and AmBisome®in murine cutaneous leishmaniasis

Authors: Wijnant GJ, Van Bocxlaer K, Yardley V, Harris A, Alavijeh M, Silva-Pedrosa R, Antunes S, Maurício I, Murdan S, Croft SL
Publication Year: 2018
Journal: International Journal for Parasitology: Drugs and Drug Resistance
Link: https://www.ncbi.nlm.nih.gov/pubmed/29673889

Fungisome® (F), a liposomal amphotericin B (AmB) product, is marketed in India as a safe and effective therapeutic for the parasitic infection visceral leishmaniasis. Its potential in the treatment of cutaneous leishmaniasis (CL), a disfiguring form of the disease affecting the skin, is currently unknown. Here, we report the evaluation of the efficacy of F in […]
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Molecular characterization of Dirofilaria spp. circulating in Portugal

Authors: Afonso A, Alho AM, Belo S, Calado M, Ferreira C, Madeira de Carvalho L, Maurício I, Meireles J
Publication Year: 2017
Journal: Parasites & Vectors
Link: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2180-y

Dirofilariosis is a potentially zoonotic parasitic disease, mainly transmitted by mosquito vectors in many parts of the world. Data concerning the canine Dirofilaria species currently circulating in Portugal is scarce. Thereby, a large-scale study was conducted to determine the Dirofilaria spp. present in Portugal, based on a molecular approach, and also to optimize a reliable […]
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In vitro and in vivo behaviour of sympatric Leishmania (V.) braziliensis, L. (V.) peruviana and their hybrids.

Authors: Campino L, Cortes S, Cristóvão JM, Esteves C, Maia C, Maurício I, Miles M
Journal: Parasitology
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=In+vitro+and+in+vivo+behaviour+of+sympatric+Leishmania+(V.)+braziliensis%2C+L.+(V.)+peruviana+and+their+hybrids.

Leishmania (Viannia) braziliensis is the main cause of highly disfiguring mucocutaneous leishmaniasis (MCL) in South America. The related species L. (V.) peruviana has only been identified in simple cutaneous lesions (CL). Hybrids between L. braziliensis and L. peruviana have been reported although genetic exchange in Leishmania is considered to be rare. Here we compared growth in vitro, adaptive capacity under thermal and oxidative stress and behaviour in a hamster model, of L. braziliensis, L. peruviana, and their putative hybrids. At 24°C, the optimal temperature for in vitro growth, L. braziliensis had the highest growth rate.
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Molecular characterization of the first record of Lymnaea natalensis Krauss 1848 (Mollusca, Pulmonata, Lymnaeidae) on Madeira Island.

Authors: Afonso A, Belo S, Brehm A, Calado M, Ferreira CC, Ferreira PM, Grácio MA, Maurício I, Parreira R
Journal: Tropical Medicine & International Health
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=31&SID=Y2ytOr2frNCuRlReLtM&page=1&doc=1

Phylogenetic Studies

Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome®and AmBisome®in murine cutaneous leishmaniasis

Molecular characterization of Dirofilaria spp. circulating in Portugal

In vitro and in vivo behaviour of sympatric Leishmania (V.) braziliensis, L. (V.) peruviana and their hybrids.

Molecular characterization of the first record of Lymnaea natalensis Krauss 1848 (Mollusca, Pulmonata, Lymnaeidae) on Madeira Island.

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