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Home / Archives for Kuhls K

Phylogenetic Studies

  • Autores: Kuhls K, Maurício I
  • Ano de Publicação: 2019
  • Journal: Methods in Molecular Biology
  • Link: https://europepmc.org/abstract/med/30980297

Phylogenetics is an important component of the systems biology approach. Knowledge about evolution of the genus Leishmania is essential to understand various aspects of basic biology of these parasites, such as parasite-host or parasite-vector relationships, biogeography, or epidemiology. Here, we present a comprehensive guideline for performing phylogenetic studies based on DNA sequence data, but with […]
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Re-Emerging foci of visceral leishmaniasis in Armenia – first molecular diagnosis of clinical samples

  • Autores: Sukiasyan A, Keshishyan A, Manukyan D, Melik-Andreasyan G, Atshemyan L, Apresyan H, Strelkova M, Frohme M, Cortes S, Kuhls K
  • Ano de Publicação: 2019
  • Journal: Parasitology
  • Link: https://www.cambridge.org/core/journals/parasitology/article/reemerging-foci-of-visceral-leishmaniasis-in-armenia-first-molecular-diagnosis-of-clinical-samples/3660B1D3BEF8F25D1EA654C99FE4D933

Visceral leishmaniasis (VL) was firstly reported in Armenia in 1913. Following a considerable increase of the number of cases until the mid 1950s, the disease disappeared after 1969 and re-emerged in 1999. Scientific literature about VL in Armenia is available only in Russian or Armenian. This paper presents a historical overview about leishmaniasis in Armenia […]
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A pilot study on fingerprinting Leishmania species from the Old World using Fourier transform infrared spectroscopy

  • Autores: Beckhoff B, Campino L, Cortes S, Emmer P, Frohme M, Hornemann A, Kuhls K, Sinning D, Ulm G
  • Ano de Publicação: 2017
  • Journal: Analytical and Bioanalytical Chemistry
  • Link: https://link.springer.com/article/10.1007%2Fs00216-017-0655-5

Leishmania species are protozoan parasites and the causative agents of leishmaniasis, a vector borne disease that imposes a large health burden on individuals living mainly in tropical and subtropical regions. Different Leishmania species are responsible for the distinct clinical patterns, such as cutaneous, mucocutaneous, and visceral leishmaniasis, with the latter being potentially fatal if left […]
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Population structure and evidence for bothclonality and recombination among Brazilian strains of the subgenus Leishmania(Viannia)

  • Autores: Boité MC, Cupolillo E, Kuhls K, Maurício I, Mello MN, Miles M, Schönian G, Schweynoch C, Silva SO, Wirth T
  • Journal: PLoS Negleted Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814519/

Parasites of the subgenus Leishmania (Viannia) cause varying clinical symptoms ranging from cutaneous leishmaniases (CL) with single or few lesions, disseminated CL (DL) with multiple lesions to disfiguring forms of mucocutaneous leishmaniasis (MCL). In this population genetics study, 37 strains of L. (V.) guyanensis, 63 of L. (V.) braziliensis, four of L. (V.) shawi, six of L. (V.) lainsoni, seven of L. (V.) naiffi, one each of L. (V.) utingensis and L. (V.) lindenbergi, and one L. (V.) lainsoni/L. naiffi hybrid from different endemic foci in Brazil were examined for variation at 15 hyper-variable microsatellite markers.
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Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin.

  • Autores: Alam MZ, Cupolillo E, Feliciangeli MD, Ferreira GE, Kuhls K, Mauricio IL, Miles MA, Oddone R, Schönian G, Wirth T
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Comparative+microsatellite+typing+of+new+world+Leishmania+infantum+reveals+low+heterogeneity+among+populations+and+its+recent+old+world+origin.

Leishmania infantum (syn. L. chagasi) is the causative agent of visceral leishmaniasis (VL) in the New World (NW) with endemic regions extending from southern USA to northern Argentina.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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